Identification of a Frameshift Mutation Resulting in Premature Termination and Loss of Cell Wall Anchoring of the PAc Antigen of Streptococcus Mutans GS-5

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1997 Feb 1

PMID 9009344

Citations 13

Authors

Y Murakami

Y Nakano

Y Yamashita

T Koga

Affiliations

Soon will be listed here.

Abstract

Most strains of Streptococcus mutans possess a 190-kDa protein antigen (PAc) on their cell surfaces, while strain GS-5 produces extracellularly a 155-kDa PAc protein. The pac gene of strain GS-5 consists of 3,477 bp and codes for a protein of 1,158 amino acids. One insertion of an adenine into the 3,469th, 3,470th, or 3,471st position from the start codon results in a frameshift mutation at codon 1157 with subsequent termination after 3 additional codons.

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