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P G MUNDER

Explore the profile of P G MUNDER including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 60
Citations 394
Followers 0
Related Specialties
Oncology
Biochemistry
Allergy & Immunology
Top 10 Co-Authors
M Modolell
R Andreesen
E FERBER
H Fischer
W E Berdel
O Westphal
W J Houlihan
G A Luckenbach
H U Weltzien
J Rastetter
Published In
J Natl Cancer Inst
Anticancer Res
Int Arch Allergy Appl Immunol
Cancer Res
Lipids
Affiliations
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Recent Articles
1.
Antitumor activity of the R- and S-enantiomers of RS-2-[[hydroxy[[2-[ (octadecyloxy)methyl]tetrahydrofuran-2-yl]methoxy]-phosphinyl]oxy]-N, N,N,-trimethylethylaminium hydroxide inner salt
Houlihan W, Prasad K, Underwood R, Repic O, MUNDER P
J Med Chem . 1996 Jan; 39(2):605-8. PMID: 8558533
The R- and S-enantiomers of 2-[[hydroxyl[[2-[(octadecyloxy) methyl]tetrahydrofuran-2-yl]methoxy]-phosphinyl]oxy]-N,N,N,- trimethylethylaminium hydroxide salt (SRI 62-834) have been evaluated in several assays to determine potential antitumor activity. The S-enantiomer showed slightly greater cytotoxic activity...
2.
Preclinical pharmacology and possible mechanism of action of the novel antitumor agent 5-(4'-piperidinomethylphenyl)-2,3-dihydroimidazo [2,1-a]isoquinoline
Houlihan W, MUNDER P, Handley D, Nemecek G
Arzneimittelforschung . 1995 Oct; 45(10):1133-7. PMID: 8595076
SDZ 62-434 (CAS 115621-95-9, 5-(4'-piperidinomethylphenyl)-2,3-dihydroimidazo [2,1-a]isoquinoline dihydrochloride), a member of a novel class of antitumor agents, exhibited direct and macrophage-induced cytotoxicity against a variety of murine tumor cell lines. It...
3.
Antitumor activity of 5-aryl-2,3-dihydroimidazo[2,1-a]isoquinolines
Houlihan W, MUNDER P, Handley D, Cheon S, PARRINO V
J Med Chem . 1995 Jan; 38(2):234-40. PMID: 7830265
A series of 5-aryl-2,3-dihydroimidazo[2,1-a]isoquinolines previously reported to be platelet activating factor (PAF) receptor antagonists were evaluated for potential antitumor activity. Several compounds, such as the 5-(4'-tert-butylphenyl) (65), 5-[4'-(trimethylsilyl)phenyl] (69), and...
4.
Antitumor activity of a piperidine phospholipid
Houlihan W, Lee M, MUNDER P, Handley D, Nemecek G, Jaeggi C, et al.
Arzneimittelforschung . 1994 Dec; 44(12):1384-8. PMID: 7848363
A piperidine phospholipid ((+/-)-2-[hydroxy] [1-octadecyloxycarbonylpiperidin-3-yl]methoxy-phosphinyl] oxy]-N,N,N, trimethylethaniminium hydroxide inner salt, SDZ 62-826) has been prepared that exhibited weak direct cytotoxicity and strong macrophage-induced cytotoxicity in vitro against a variety of...
5.
Macrophage mediated tumor cell destruction measured by an alkaline phosphatase assay
Modolell M, MUNDER P
J Immunol Methods . 1994 Sep; 174(1-2):203-8. PMID: 8083522
A new assay to measure the cytotoxic or growth-inhibitory activity of macrophages against tumor cells is described. The method is based on the fact that, in contrast to macrophages, natural...
6.
Age-related changes in interleukin production in BALB/cNNia and SJL/J mice and their modification after administration of foreign macromolecules
Gorczynski R, DUBISKI S, MUNDER P, Cinader B, Westphal O
Immunol Lett . 1993 Nov; 38(3):243-51. PMID: 8125531
In vitro production of Interleukin-2, -3, -4 and -10 by activated lymphocytes of BALB/cNNia and SJL/J was studied. While IL-2 production in BALB/c mice remains constant throughout the life span...
7.
Differential modulation of the effects of lipopolysaccharide on macrophages by a major outer membrane protein of Proteus mirabilis
Weber G, Link F, FERBER E, MUNDER P, Zeitter D, Bartlett R, et al.
J Immunol . 1993 Jul; 151(1):415-24. PMID: 8326134
We previously showed that a major protein isolated from purified cell walls of Proteus mirabilis (39-kDa protein) is a strong modulator of the specific immune responses to LPS from this...
8.
Alkyllysophospholipid prevents induction of experimental allergic encephalomyelitis
Klein-Franke A, MUNDER P
J Autoimmun . 1992 Feb; 5(1):83-91. PMID: 1373062
Alkyllysophospholipids are synthetic analogues of natural phospholipids possessing a high immunomodulating and antitumoral capacity. Experimental autoimmune encephalomyelitis is a model disease for multiple sclerosis which can be induced by injecting...
9.
Antitumor activity of Ilmofosine (BM 41.440) in the 3Lewis-lung carcinoma model
Herrmann D, Opitz H, MUNDER P
Lipids . 1991 Dec; 26(12):1431-6. PMID: 1819746
Ilmofosine (1-hexadecylthio-2-methoxymethyl-1,3-propanediol-phosphocholine, BM 41.440) is a thioether phospholipid with cytostatic/cytotoxic properties. The antineoplastic activity of this compound was investigated in vivo in the 3Lewis-lung carcinoma system. 3Lewis lung tumor-bearing C57Bl/6...
10.
Cyclic oxygen analogues of alkyl-lysophospholipids. Synthesis and neoplastic cell growth inhibitory properties
Houlihan W, Lee M, MUNDER P, Winslow C, Cheon S, DAries F, et al.
J Lipid Mediat . 1990 Sep; 2(5):295-307. PMID: 2133273
Ether phospholipids have demonstrated both in vitro and in vivo activity against a wide variety of tumor cell lines. The known cyclic ether phospholipid, SRI 62-834, was used as the...