The Origin of Human Triploids

Overview

Journal Ann Hum Genet

Date 1978 Jul 1

PMID 686684

Citations 35

Authors

P A Jacobs

R R Angell

I M Buchanan

T J Hassold

A M Matsuyama

B Manuel

Affiliations

Soon will be listed here.

Abstract

A series of 26 triploid foetuses was ascertained in a survey of spontaneous abortuses and the origin of the additional haploid complement determined in 21 of them by the study of foetal and parental heteromorphisms. In 17 the additional haploid set was paternal in origin, in 3 it was maternal in origin and in one the parental origin could not be determined. The best fit for the data using a maximum-likelihood method was that 66.4% of the triploids were the result of dispermy, 23.6% the result of fertilization of a haploid ovum by a diploid sperm formed by failure of the first meiotic division in the male and 10% the result of a diploid egg formed by failure of the first maternal meiotic division. The possible sources of error inherent in the technique are reviewed and our results compared with previously published data.

Citing Articles

Chromosomal Abnormalities in Miscarriages and Maternal Age: New Insights from the Study of 7118 Cases.

Pendina A, Krapivin M, Chiryaeva O, Petrova L, Pashkova E, Golubeva A Cells. 2025; 14(1.

PMID: 39791709 PMC: 11720377. DOI: 10.3390/cells14010008.

Incidence of haploidy and triploidy in trophectoderm biopsies of blastocysts derived from normally and abnormally fertilized oocytes.

Girardi L, Patassini C, Miravet Valenciano J, Sato Y, Fagundes Cagnin N, Castellon J J Assist Reprod Genet. 2024; 41(12):3357-3370.

PMID: 39378000 PMC: 11707209. DOI: 10.1007/s10815-024-03278-4.

A Novel System for the Detection of Spontaneous Abortion-Causing Aneuploidy and Its Erroneous Chromosome Origins through the Combination of Low-Pass Copy Number Variation Sequencing and NGS-Based STR Tests.

Lei C, Liao K, Zhao Y, Long Z, Zhu S, Wu J J Clin Med. 2023; 12(5).

PMID: 36902595 PMC: 10003649. DOI: 10.3390/jcm12051809.

Triploidy in a Live-Born Extremely Low Birth Weight Twin: Clinical Aspects.

Vakrilova L, Hitrova-Nikolova S, Bradinova I J Pediatr Genet. 2022; 11(3):227-231.

PMID: 35990033 PMC: 9385251. DOI: 10.1055/s-0040-1716828.

When embryology meets genetics: the definition of developmentally incompetent preimplantation embryos (DIPE)-the consensus of two Italian scientific societies.

Cimadomo D, Capalbo A, Scarica C, Sosa Fernandez L, Rienzi L, Ciriminna R J Assist Reprod Genet. 2020; 38(2):319-331.

PMID: 33236289 PMC: 7884494. DOI: 10.1007/s10815-020-02015-x.