T J Hassold
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Explore the profile of T J Hassold including associated specialties, affiliations and a list of published articles.
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53
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1281
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Recent Articles
1.
Lamb N, Sherman S, Hassold T
Cytogenet Genome Res
. 2005 Sep;
111(3-4):250-5.
PMID: 16192701
Within the last decade, aberrant meiotic recombination has been confirmed as a molecular risk factor for chromosome nondisjunction in humans. Recombination tethers homologous chromosomes, linking and guiding them through proper...
2.
Thomas N, Hassold T
Hum Reprod Update
. 2003 Aug;
9(4):309-17.
PMID: 12926525
Trisomy is the most commonly identified chromosome abnormality in humans, occurring in at least 4% of all clinically recognized pregnancies; it is the leading known cause of pregnancy loss and...
3.
Hassold T, Burrage L, Chan E, Judis L, Schwartz S, James S, et al.
Am J Hum Genet
. 2001 Jul;
69(2):434-9.
PMID: 11443546
Attempts to identify genetic contributors to human meiotic nondisjunction have met with little, if any, success. Thus, recent reports linking Down syndrome to maternal polymorphisms at either of two folate...
4.
Yang Q, Sherman S, Hassold T, Allran K, Taft L, Pettay D, et al.
Genet Med
. 2001 May;
1(3):80-8.
PMID: 11336457
Purpose: We examined maternal smoking and oral contraceptive use as possible risk factors in the genesis of cases of trisomy 21 of maternal origin. This is the first epidemiological study...
5.
Bean C, Hunt P, Millie E, Hassold T
Hum Mol Genet
. 2001 Apr;
10(9):963-72.
PMID: 11309370
Despite the clinical importance of human aneuploidy, we know little of the causes of mammalian non-disjunction. In part, this reflects the fact that, unlike lower organisms, segregation 'impaired' chromosomes are...
6.
Thomas N, Ennis S, Sharp A, Durkie M, Hassold T, Collins A, et al.
Hum Mol Genet
. 2001 Feb;
10(3):243-50.
PMID: 11159943
Human trisomy is attributable to many different mechanisms and the relative importance of each mechanism is highly chromosome specific. The association between altered recombination and maternal non-disjunction is well documented:...
7.
Thomas N, Collins A, Hassold T, Jacobs P
Eur J Hum Genet
. 2000 Oct;
8(10):805-8.
PMID: 11039584
We have used polymorphisms within the Xp/Yp pseudoautosomal region (PAR 1) to determine the frequency and location of recombination in 80 paternally derived 47, XXY males. Of 64 informative results,...
8.
Hixon M, Wagner M, Millie E, Nagy J, Hassold T, Gualberto A
J Biol Chem
. 2000 Sep;
275(51):40434-42.
PMID: 11005810
Vascular smooth muscle cells (VSMC) at capacitance arteries of hypertensive individuals and animals undergo dramatic polyploidization that contributes toward their hypertrophic phenotype. We report here the identification of a defective...
9.
LePage D, Church D, Millie E, Hassold T, Conlon R
Proc Natl Acad Sci U S A
. 2000 Sep;
97(19):10471-6.
PMID: 10984539
Nested chromosomal deletions are powerful genetic tools. They are particularly suited for identifying essential genes in development either directly or by screening induced mutations against a deletion. To apply this...
10.
Robinson W, Christian S, Kuchinka B, Penaherrera M, Das S, Schuffenhauer S, et al.
Clin Genet
. 2000 Jun;
57(5):349-58.
PMID: 10852369
Paternal uniparental disomy (UPD) for chromosome 15 (UPD15), which is found in approximately 2% of Angelman syndrome (AS) patients, is much less frequent than maternal UPD15, which is found in...