Localisation of Tricyclic Antidepressant Binding Sites on Serotonin Nerve Terminals

Overview

Journal J Neurochem

Specialties Chemistry
Neurology

Date 1981 Jul 1

PMID 7252512

Citations 13

Authors

M Sette

R Raisman

M Briley

S Z Langer

Affiliations

Soon will be listed here.

Abstract

High-affinity specific [3H]imipramine binding has been demonstrated in the brain and platelets of various species including man. Electrolytic lesions of the rat dorsal raphe, which resulted in a significant decrease in the endogenous levels of serotonin produced a reduction in the density of [3H]imipramine binding sites in the hypothalamus and cortex. The affinity constants were unchanged. These results suggest that [3H]imipramine binding sites are located on serotonin nerve terminals.

Citing Articles

3H-Imipramine binding sites in the rat brain. Selective localization on serotoninergic neurones.

Gross G, Gothert M, Ender H, SCHUMANN H Naunyn Schmiedebergs Arch Pharmacol. 1981; 317(4):310-4.

PMID: 7322215 DOI: 10.1007/BF00501311.

3H-imipramine binding and serotonin uptake in platelets from untreated depressed patients and control volunteers.

Raisman R, Briley M, Bouchami F, Sechter D, Zarifian E, Langer S Psychopharmacology (Berl). 1982; 77(4):332-5.

PMID: 6813892 DOI: 10.1007/BF00432765.

3H-Imipramine high-affinity binding sites in rat brain. Effects of imipramine and lithium.

Plenge P, Mellerup E Psychopharmacology (Berl). 1982; 77(1):94-7.

PMID: 6812124 DOI: 10.1007/BF00436105.

High-affinity 3H-imipramine binding in platelets from untreated and treated depressed patients compared to healthy volunteers.

Raisman R, Sechter D, Briley M, Zarifian E, Langer S Psychopharmacology (Berl). 1981; 75(4):368-71.

PMID: 6803282 DOI: 10.1007/BF00435855.

Proceedings of the British Pharmacological Society, University of Cambridge, 6th-8th April, 1983. Abstracts.

Br J Pharmacol. 1983; 79 Suppl:188P-425P.

PMID: 6652364 PMC: 2044764.