Regional Distribution of [3H]imipramine Binding in Rat Brain

Overview

Journal Brain Res

Specialty Neurology

Date 1981 Apr 6

PMID 7225822

Citations 12

Authors

M Palkovits

R Raisman

M Briley

S Z Langer

Affiliations

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Abstract

[3H]imipramine binding was measured in 23 microdissected areas of the rat brain and compared to published values for the endogenous levels of serotonin, noradrenaline and dopamine in the same areas. The density of [3H]imipramine binding sites appears to be highly correlated with the distribution of endogenous serotonin especially where the serotonin is located mainly in nerve terminals. A weak but still significant correlation also exists with the distribution of endogenous noradrenaline whereas no such correlation could be detected for endogenous dopamine.

Citing Articles

High affinity [3H]imipramine and [3H]paroxetine binding sites in suicide brains.

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PMID: 9451724 DOI: 10.1007/BF01285560.

Regional distribution of specific high affinity binding sites for 3H-imipramine and 3H-paroxetine in human brain.

Rosel P, Menchon J, Oros M, Vallejo J, Cortadellas T, Arranz B J Neural Transm (Vienna). 1997; 104(1):89-96.

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Molecular mechanisms in the action of imipramine.

Costa E, Chuang D, Barbaccia M, Gandolfi O Experientia. 1983; 39(8):855-8.

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3H-imipramine binding and serotonin uptake in platelets from untreated depressed patients and control volunteers.

Raisman R, Briley M, Bouchami F, Sechter D, Zarifian E, Langer S Psychopharmacology (Berl). 1982; 77(4):332-5.

PMID: 6813892 DOI: 10.1007/BF00432765.

High-affinity 3H-imipramine binding in platelets from untreated and treated depressed patients compared to healthy volunteers.

Raisman R, Sechter D, Briley M, Zarifian E, Langer S Psychopharmacology (Berl). 1981; 75(4):368-71.

PMID: 6803282 DOI: 10.1007/BF00435855.