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Aberrant Rearrangements Contribute Significantly to the Allelic Exclusion of Immunoglobulin Gene Expression

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Journal Nature
Specialty Science
Date 1981 Apr 2
PMID 6783959
Citations 109
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Abstract

A study of the organization of light- and heavy-chain immunoglobulin genes in mouse splenic B cells, spleen-derived hybridomas and plasmacytomas has unequivocally demonstrated that aberrant rearrangements are common during normal B-cell development. The results support a probabilistic model for allelic exclusion of immunoglobulin gene expression.

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