Autoreactive B Cells in the Marginal Zone That Express Dual Receptors

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 2002 Jan 24

PMID 11805145

Citations 104

Authors

Yijin Li

Hui Li

Martin Weigert

Affiliations

Soon will be listed here.

Abstract

Allotype and isotype exclusion is a property of most lymphocytes. The reason for this property is not known but it guarantees a high concentration of a single receptor, and threshold numbers of receptors may be required for efficient positive and negative selection. Receptor editing compromises exclusion by sustaining recombination even after a functional receptor is formed. Consequently, B cells expressing multiple receptors arise. We have studied such B cells in which one of the two receptors is anti-self, and find that these partially autoreactive B cells accumulate in the marginal zone. The restriction of these cells in this location may help to prevent them from undergoing diversification and developing into fully autoreactive B cells.

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