Double Light Chain Producing Lymphocytes: an Enigma of Allelic Exclusion

Overview

Journal Immunol Res

Specialty Allergy & Immunology

Date 2002 Jan 31

PMID 11817327

Authors

L Diaw

D Siwarski

K Huppi

Affiliations

Soon will be listed here.

Abstract

The infrequent double light chain producing lymphocyte (DLCPL) is discussed in the context of allelic exclusion. Principally allelic selection rather than allelic exclusion would suggest a role for the DLCPL in the normal B cell population rather than as an aberrance of B cell malignancy. Found primarily in the periphery, it is uncertain at what stage of B cell ontogeny the DLCPL might reside. Nevertheless, through the possible presentation of two functional surface receptors, the DLCPL could be capable of recognizing both self and nonself epitopes.

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