Age-dependent Changes in Brain Protein Synthesis in the Rat

Overview

Journal Neurochem Res

Specialties Chemistry
Neurology

Date 1980 Apr 1

PMID 6770276

Citations 18

Authors

J L Fando

M Salinas

C G Wasterlain

Affiliations

Soon will be listed here.

Abstract

Brain protein synthesis was studied in vivo, in brain slices, and in cell-free systems in rats aged 1, 16, and 24 months. We observed a highly significant reduction in amino acid incorporation with advancing age. This reduction was observed in vivo, in slices, in postmitochondrial supernatant, microsomes, and membrane-bound polysomes. Free heavy polysomes showed no age-dependent decline but formed a smaller proportion of total ribosomes in older animals. These studies suggest that in the rat brain protein synthesis declines before senescence, possibly due to an impairment in the initiation process.

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