Histopathology of the Synovial Membrane of Peripheral Joints in Ankylosing Spondylitis

Overview

Journal Ann Rheum Dis

Specialty Rheumatology

Date 1982 Dec 1

PMID 6756321

Citations 24

Authors

P A Revell

V Mayston

Affiliations

Soon will be listed here.

Abstract

The histological features of the synovial membrane of peripheral joints in ankylosing spondylitis are similar to those seen in rheumatoid arthritis. There is intimal cell hyperplasia, a diffuse lymphocyte and plasma cell infiltrate, and formation of lymphoid follicles. Peroxidase-antiperoxidase staining shows the presence of IgG-, IgA-, and IgM-containing plasma cells in ankylosing spondylitis. The percentage of IgM-containing cells is significantly lower in ankylosing spondylitis than in rheumatoid arthritis.

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References

Cooper N, Soren A, McEwen C, Rosenberger J . Diagnostic specificity of synovial lesions. Hum Pathol. 1981; 12(4):314-28. DOI: 10.1016/s0046-8177(81)80141-4. View

Mestecky J, Miller E . Presence of antibodies specific to cartilage-type collagen in rheumatoid synovial tissue. Clin Exp Immunol. 1975; 22(3):453-6. PMC: 1538442. View

Male D, Roitt I, Hay F . Analysis of immune complexes in synovial effusions of patients with rheumatoid arthritis. Clin Exp Immunol. 1980; 39(2):297-306. PMC: 1538046. View

McCormick J . An Immunofluorescence Study of Rheumatoid Factor. Ann Rheum Dis. 1963; 22(1):1-10. PMC: 1007316. DOI: 10.1136/ard.22.1.1. View

BONOMO L, Tursi A, Gillardi U . Distribution of the anti-gamma globulin factors in the synovial membrane and other tissues in various diseases. Ann Rheum Dis. 1968; 27(2):122-9. PMC: 1031078. DOI: 10.1136/ard.27.2.122. View

Cracchiolo 3rd A, Barnett E . Immunologic changes in synovial fluid following synovectomy of the knee for rheumatoid arthritis. J Bone Joint Surg Am. 1969; 51(3):475-86. View

Friis J . Immunohistochemical demonstration of rheumatoid factor (RF) in alcohol-fixed synovial tissue from patients with rheumatoid arthritis (RA). Acta Pathol Microbiol Scand. 1969; 75(1):71-84. View

Munthe E, Natvig J . Immunglobulin classes, subclasses and complexes of IgG rheumatoid factor in rheumatoid plasma cells. Clin Exp Immunol. 1972; 12(1):55-70. PMC: 1553640. View

CRUICKSHANK B . Histopathology of diarthrodial joints in ankylosing spondylitis. Ann Rheum Dis. 1951; 10(4):393-404. PMC: 1030704. DOI: 10.1136/ard.10.4.393. View

10.

. DIAGNOSTIC criteria for rheumatoid arthritis: 1958 revision by a committee of the American Rheumatism Association. Ann Rheum Dis. 1959; 18(1):49-51. PMC: 1007378. View

11.

Julkunen H . Synovial inflammatory cell reaction in chronic arthritis. Acta Rheumatol Scand. 1966; 12(3):188-96. DOI: 10.3109/rhe1.1966.12.issue-1-4.22. View

12.

BONOMO L, Tursi A, Trizio D, Gillardi U, Dammacco F . Immune complexes in rheumatoid synovitis: a mixed staining immunofluorescence study. Immunology. 1970; 18(4):557-63. PMC: 1455492. View

13.

Wagner T . The microscopic appearance of synovial membranes in peripheral joints in ankylosing spondylitis. Reumatologia. 1970; 8(3):209-15. View

14.

MELLORS R, NOWOSLAWSKI A, Korngold L, SENGSON B . Rheumatoid factor and the pathogenesis of rheumatoid arthritis. J Exp Med. 1961; 113:475-84. PMC: 2137350. DOI: 10.1084/jem.113.2.475. View

15.

Ball J, NEL-D BAHGAT , Taylor G . EFFECT OF ALDEHYDR FIXATION ON CELLULAR RHEUMATOID FACTOR AND CERTAIN TISSUE ANTIGENS. J Histochem Cytochem. 1964; 12:737-9. DOI: 10.1177/12.10.737. View

16.

SLIWINSKI A, Zvaifler N . In vivo synthesis of IgG by rheumatoid synovium. J Lab Clin Med. 1970; 76(2):304-10. View

17.

Goldenberg D, Cohen A . Synovial membrane histopathology in the differential diagnosis of rheumatoid arthritis, gout, pseudogout, systemic lupus erythematosus, infectious arthritis and degenerative joint disease. Medicine (Baltimore). 1978; 57(3):239-52. DOI: 10.1097/00005792-197805000-00004. View

18.

Fyrand O, Mellbye O, Natvig J . Immunofluorescence studies for immunoglobulins and complement C3 in synovial joint membranes in psoriatic arthritis. Clin Exp Immunol. 1977; 29(3):422-7. PMC: 1541064. View

19.

BEKEMEIER H . [Evolution skin pigmentation and cutaneous vitamin D photosynthesis]. Dtsch Med Wochenschr. 1969; 94(4):185. DOI: 10.1055/s-0028-1108925. View