Presence of Antibodies Specific to Cartilage-type Collagen in Rheumatoid Synovial Tissue

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1975 Dec 1

PMID 1225486

Citations 13

Authors

J Mestecky

E J Miller

Affiliations

Soon will be listed here.

Abstract

Synovial membranes of rheumatoid arthritis patients were examined by fluorescence microscopy for the presence of cells producing different classes of immunoglobulins and for the incidence of antibodies to human collagens. IgG and IgM immunoglobulins were detected while IgA, IgD and IgE were absent. When consecutive tissue sections were incubated with tetramethylrhodamine isothiocyanate-labelled collagen preparations, prominent cellular and extra-cellular staining was observed only with cartilage-derived Type II collagen.

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