The Role of the Gut and Microbes in the Pathogenesis of Spondyloarthritis

Overview

Journal Best Pract Res Clin Rheumatol

Publisher Elsevier

Specialty Rheumatology

Date 2014 Dec 10

PMID 25488778

Citations 42

Authors

Mark Asquith

Dirk Elewaut

Phoebe Lin

James T Rosenbaum

Affiliations

Soon will be listed here.

Abstract

The intestinal microbiota is firmly implicated not only in the pathogenesis of inflammatory bowel disease (IBD) but increasingly also in the development of inflammation at extraintestinal tissue sites. Significant clinical, genetic, immunological, and microbiological overlap exists between IBD and spondyloarthritis (SpA), which indicates that pathophysiological mechanisms are shared between these diseases and may center on the intestinal microbiota. Recently, culture-independent techniques have enabled the microbiota in health and disease to be described in increasing detail. Moreover, functional studies have identified myriad host effector and regulatory pathways that shape or are shaped by this microbial community. We consider the complex relationship between SpA pathogenesis and gut microbes, with a discussion of how manipulation of the gut microbiota itself may be a promising future target for SpA therapy.

Citing Articles

[Microbial and genetic factors in the pathogenesis of spondyloarthritis].

Rademacher J, Poddubnyy D, Rios Rodriguez V Z Rheumatol. 2024; .

PMID: 39621045 DOI: 10.1007/s00393-024-01593-w.

Elevated Calprotectin Levels Reveal Loss of Vascular Pattern and Atrophy of Villi in Ileum by Digital Chromoendoscopy and Magnification Colonoscopy in Patients with Spondyloarthritis Without Having Inflammatory Bowel Disease.

Avila J, Florez-Sarmiento C, Parra-Izquierdo V, Bautista-Molano W, Chamorro-Melo M, Beltran-Ostos A Diagnostics (Basel). 2024; 14(22).

PMID: 39594257 PMC: 11593260. DOI: 10.3390/diagnostics14222591.

Unveiling the Potential of Probiotics in Osteoarthritis Management.

Karim A Curr Rheumatol Rep. 2024; 27(1):2.

PMID: 39579259 DOI: 10.1007/s11926-024-01166-5.

Immunologic derangement caused by intestinal dysbiosis and stress is the intrinsic basis of reactive arthritis.

He T, Qian W Z Rheumatol. 2024; 83(Suppl 3):305-313.

PMID: 38403666 PMC: 11655581. DOI: 10.1007/s00393-024-01480-4.

Exploring the relationship between and in inflammatory bowel disease (IBD): Insights and implications.

Cabezas-Cruz A, Bermudez-Humaran L Comput Struct Biotechnol J. 2023; 23:1-9.

PMID: 38094217 PMC: 10716368. DOI: 10.1016/j.csbj.2023.11.027.

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