The Effect of Mitogenic Lectins and Monoclonal Antibodies on Intracellular Free Calcium Concentration in Human T-lymphocytes

Overview

Journal Biochem J

Specialty Biochemistry

Date 1984 Apr 15

PMID 6611152

Citations 10

Authors

K OFlynn

D C Linch

P E Tatham

Affiliations

Soon will be listed here.

Abstract

The effect of mitogenic lectins and the mitogenic antibody UCHT1 on the cytoplasmic free Ca2+ concentration ( [Ca2+]i) in human lymphocytes was investigated by using the fluorescent Ca2+-indicator quin2 . Phytohaemagglutinin, concanavalin A and UCHT1 increased [Ca2+]i in T-cells to a maximum level within 2 min. No T-cell response was seen with poke weed mitogen. None of the mitogens affected non-T-cell [Ca2+]i.

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