Induction of Increased Calcium Uptake in Mouse T Lymphocytes by Concanavalin A and Its Modulation by Cyclic Nucleotides

Overview

Journal Nature

Specialty Science

Date 1975 May 29

PMID 165431

Citations 39

Authors

M H Freedman

M C Raff

Affiliations

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Abstract

The binding of concanavqlin A to T but not B mouse spleen lymphocytes increases Ca-2+ uptake in these cells which is measurable by 45 s and complete by 1 min. Dibutyrl cyclic AMP, but not sodium azide inhibits induced Ca-2+ uptake, wheras dibutyryl cyclic GMP enhances it. B cell mitogens do not cause a similar Ca-2+ uptake in mouse B lymphocytes. The induction of increased Ca-2+ uptake by T cells is discussed in terms of gated membrane channels for Ca-2+.

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