Mitogenicity of Naegleria Fowleri Extract for Murine T Lymphocytes

Overview

Journal Immunology

Specialty Allergy & Immunology

Date 1984 Mar 1

PMID 6607875

Citations 5

Authors

A Ferrante

C Smyth

Affiliations

Soon will be listed here.

Abstract

The whole-killed pathogenic free-living amoeba, Naegleria fowleri, contained mitogenic activity (NFM) for mouse spleen cells. Similar preparations from the non-pathogenic amoeba N. gruberi and the pathogenic Acanthamoeba culbertsoni lacked mitogenic activity. Fluids from N. fowleri cultures, containing amoeba antigens, also failed to cause proliferation of mouse spleen lymphocytes. Spleen cells from athymic nude mice failed to respond to NFM. In addition, nylon wool non-adherent, but not the adherent, spleen cell subpopulation proliferated in the presence of NFM. These results show that the factor(s) is mitogenic for T lymphocytes. The spleen cells from mice treated with cyclophosphamide doses known to deplete T suppressor cell activity from this organ failed to respond to NFM, indicating that NFM may be mitogenic for T suppressor cells.

Citing Articles

Migration patterns of pathogenic and nonpathogenic Naegleria spp.

Thong Y, Ferrante A Infect Immun. 1986; 51(1):177-80.

PMID: 3940994 PMC: 261082. DOI: 10.1128/iai.51.1.177-180.1986.

The role of antibody in immunity against experimental naegleria meningoencephalitis ('amoebic meningitis').

Ferrante A, Rowan-Kelly B Immunology. 1988; 64(2):241-4.

PMID: 3391642 PMC: 1384949.

Biology of Naegleria spp.

Marciano-Cabral F Microbiol Rev. 1988; 52(1):114-33.

PMID: 3280964 PMC: 372708. DOI: 10.1128/mr.52.1.114-133.1988.

Role of myeloperoxidase in the killing of Naegleria fowleri by lymphokine-altered human neutrophils.

Ferrante A, Hill N, Abell T, Pruul H Infect Immun. 1987; 55(5):1047-50.

PMID: 3032797 PMC: 260466. DOI: 10.1128/iai.55.5.1047-1050.1987.

Production of tumor necrosis factors alpha and beta by human mononuclear leukocytes stimulated with mitogens, bacteria, and malarial parasites.

Ferrante A, Staugas R, Rowan-Kelly B, Bresatz S, Kumaratilake L, Rzepczyk C Infect Immun. 1990; 58(12):3996-4003.

PMID: 2254024 PMC: 313767. DOI: 10.1128/iai.58.12.3996-4003.1990.

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