Activation of Human Peripheral Blood Lymphocytes by a Trypanosome-derived Mitogen

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1981 Sep 1

PMID 6978210

Citations 7

Authors

M E Selkirk

B M Ogilvie

T A Platts-Mills

Affiliations

Soon will be listed here.

Abstract

Activation of human peripheral blood lymphocytes from unsensitized donors by fractions of T.b rhodesiense has been demonstrated in vitro. Both T and B cells were stimulated to differentiate into blast cells. Purified T cells failed to proliferate, but did so when mitomycin C-treated non-T cells were added. Non-T cell proliferation (weak in comparison to the T cell response) was shown to be T-dependent. In unseparated cell cultures. cultures, IgM synthesis was enhanced, whilst IgG synthesis was unaltered. However, reconstitution of non-T cells with equal number of irradiated T cells resulted in enhanced IgG synthesis. Thus neither T nor B cells were activated directly, but required the co-operation of accessory cells to proliferate. The role of monocytes in the regulation of this response requires further assessment.

Citing Articles

In vitro induction of lymphocyte responsiveness by a Strongylus vulgaris-derived mitogen.

Bailey M, Lloyd S, Martin S, Soulsby E Z Parasitenkd. 1984; 70(2):229-42.

PMID: 6609495 DOI: 10.1007/BF00942226.

Mitogenicity of Naegleria fowleri extract for murine T lymphocytes.

Ferrante A, Smyth C Immunology. 1984; 51(3):461-8.

PMID: 6607875 PMC: 1454447.

In vitro induction of human helper T cell activity by Trypanosoma brucei.

Selkirk M, Wilkins S, Ogilvie B, Platts-Mills T Clin Exp Immunol. 1983; 52(3):512-8.

PMID: 6223728 PMC: 1536021.

High and low responsiveness of bovine lymphocytes to Trypanosoma brucei in vitro: lack of correlation with resistance to trypanosomiasis.

Fumoux F, Queval R, Pinder M, Roelants G Immunology. 1985; 54(1):195-203.

PMID: 3871728 PMC: 1454855.

Polyclonal B-cell-activating factors produced by spleen cells of mice stimulated with a cell homogenate of Trypanosoma gambiense.

Oka M, Ito Y Infect Immun. 1987; 55(12):3162-7.

PMID: 2890585 PMC: 260043. DOI: 10.1128/iai.55.12.3162-3167.1987.

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