H2A.F: an Extremely Variant Histone H2A Sequence Expressed in the Chicken Embryo

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1983 May 1

PMID 6574451

Citations 37

Authors

R P Harvey

J A WHITING

L S Coles

P A Krieg

J R Wells

Affiliations

Soon will be listed here.

Abstract

A cDNA clone bank has been constructed from chicken embryonic RNA. Clones hybridizing poorly to embryonic histone gene probes were selected as possible variant gene transcripts. The DNA sequence of one cDNA predicts an extremely variant H2A protein (H2A.F), which is 40% divergent from the most abundant H2A protein in chicken erythrocyte chromatin. The H2A.F gene is not highly conserved across large species barriers, but in the chicken there may be a family of linked genes. The H2A.F mRNA is approximately equal to 820 base pairs in length and, unlike most other histone mRNAs, is polyadenylylated. Significantly, the H2A.F transcript shows a limited tissue distribution in the chicken embryo.

Citing Articles

Deciphering the Enigma of the Histone H2A.Z-1/H2A.Z-2 Isoforms: Novel Insights and Remaining Questions.

Cheema M, Good K, Kim B, Soufari H, OSullivan C, Freeman M Cells. 2020; 9(5).

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Myb proteins regulate expression of histone variant H2A.Z during thymocyte development.

Hooper J, Maurice D, Argent-Katwala M, Weston K Immunology. 2007; 123(2):282-9.

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H2A.Z has a function reminiscent of an activator required for preferential binding to intergenic DNA.

Larochelle M, Gaudreau L EMBO J. 2003; 22(17):4512-22.

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The nonessential H2A N-terminal tail can function as an essential charge patch on the H2A.Z variant N-terminal tail.

Ren Q, Gorovsky M Mol Cell Biol. 2003; 23(8):2778-89.

PMID: 12665578 PMC: 152558. DOI: 10.1128/MCB.23.8.2778-2789.2003.

Growth regulation of human variant histone genes and acetylation of the encoded proteins.

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