Antibody in Host Defense Against Mouse Pneumonitis Agent (murine Chlamydia Trachomatis)

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1984 Sep 1

PMID 6469353

Citations 18

Authors

D M Williams

J Schachter

M H Weiner

B Grubbs

Affiliations

Soon will be listed here.

Abstract

In a murine model of chlamydial pneumonia employing murine Chlamydia trachomatis, immune serum given intranasally delayed death in nude (nu/nu) mice and prevented death in nu/+ mice. Serum-derived immunoglobulin G and A fractions and immune lavage fluid fractions containing immunoglobulins G and A were effective in producing protection when used to opsonize the murine C. trachomatis inoculum. In hyperclean mice (previously made germfree and then colonized with a limited flora nonpathogenic to mice) antibody given intravenously was ineffective. The effects of antibody and nonspecific stimulation of cell-mediated immunity (after previous infection with Histoplasma capsulatum) were additive in increasing host resistance to murine C. trachomatis.

Citing Articles

Complement factor C5 but not C3 contributes significantly to hydrosalpinx development in mice infected with Chlamydia muridarum.

Yang Z, Conrad T, Zhou Z, Chen J, Dutow P, Klos A Infect Immun. 2014; 82(8):3154-63.

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Divergent outcomes following transcytosis of IgG targeting intracellular and extracellular chlamydial antigens.

Armitage C, OMeara C, Harvie M, Timms P, Blumberg R, Beagley K Immunol Cell Biol. 2014; 92(5):417-26.

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Perforin is detrimental to controlling [corrected] C. muridarum replication in vitro, but not in vivo.

Johnson R, Kerr M, Slaven J PLoS One. 2013; 8(5):e63340.

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A new role of the complement system: C3 provides protection in a mouse model of lung infection with intracellular Chlamydia psittaci.

Bode J, Dutow P, Sommer K, Janik K, Glage S, Tummler B PLoS One. 2012; 7(11):e50327.

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T lymphocyte immunity in host defence against Chlamydia trachomatis and its implication for vaccine development.

Yang X, Brunham R Can J Infect Dis. 2012; 9(2):99-108.

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References

Tagliabue A, Nencioni L, Villa L, Keren D, Lowell G, Boraschi D . Antibody-dependent cell-mediated antibacterial activity of intestinal lymphocytes with secretory IgA. Nature. 1983; 306(5939):184-6. DOI: 10.1038/306184a0. View

Brunham R, Kuo C, Cles L, Holmes K . Correlation of host immune response with quantitative recovery of Chlamydia trachomatis from the human endocervix. Infect Immun. 1983; 39(3):1491-4. PMC: 348123. DOI: 10.1128/iai.39.3.1491-1494.1983. View

Wang S, GRAYSTON J . Immunologic relationship between genital TRIC, lymphogranuloma venereum, and related organisms in a new microtiter indirect immunofluorescence test. Am J Ophthalmol. 1970; 70(3):367-74. DOI: 10.1016/0002-9394(70)90096-6. View

Nichols R, Oertley R, Fraser E, MacDONALD A, McComb D . Immunity to chlamydial infections of the eye. VI. Homologous neutralization of trachoma infectivity for the owl monkey conjuctivae by eye secretions from humans with trachoma. J Infect Dis. 1973; 127(4):429-32. DOI: 10.1093/infdis/127.4.429. View

MURRAY E, Charbonnet L, MacDONALD A . Immunity to chlamydial infections of the eye. I. The role of circulatory and secretory antibodies in resistance to reinfection with guinea pig inclusion conjunctivitis. J Immunol. 1973; 110(6):1518-25. View

Ryning F, Remington J . Effect of alveolar macrophages on Toxoplasma gondii. Infect Immun. 1977; 18(3):746-53. PMC: 421298. DOI: 10.1128/iai.18.3.746-753.1977. View

Wyrick P, Brownridge E . Growth of Chlamydia psittaci in macrophages. Infect Immun. 1978; 19(3):1054-60. PMC: 422295. DOI: 10.1128/iai.19.3.1054-1060.1978. View

Wyrick P, Brownridge E, Ivins B . Interaction of Chlamydia psittaci with mouse peritoneal macrophages. Infect Immun. 1978; 19(3):1061-7. PMC: 422296. DOI: 10.1128/iai.19.3.1061-1067.1978. View

Ey P, Prowse S, JENKIN C . Isolation of pure IgG1, IgG2a and IgG2b immunoglobulins from mouse serum using protein A-sepharose. Immunochemistry. 1978; 15(7):429-36. DOI: 10.1016/0161-5890(78)90070-6. View

10.

Kindred B . Nude mice in immunology. Prog Allergy. 1979; 26:137-238. View

11.

Johnson W, Balish E . Macrophage function in germ-free, athymic (nu/nu), and conventional-flora (nu/+) mice. J Reticuloendothel Soc. 1980; 28(1):55-66. View

12.

Williams D, Schachter J, Drutz D, Sumaya C . Pneumonia due to Chlamydia trachomatis in the immunocompromised (nude) mouse. J Infect Dis. 1981; 143(2):238-41. DOI: 10.1093/infdis/143.2.238. View

13.

Taylor G, Howard C . Protection of mice against Mycoplasma pulmonis infection using purified mouse immunoglobulins: comparison between protective effect and biological properties of immunoglobulin classes. Immunology. 1981; 43(3):519-25. PMC: 1555062. View

14.

Williams D, Schachter J, Grubbs B, Sumaya C . The role of antibody in host defense against the agent of mouse pneumonitis. J Infect Dis. 1982; 145(2):200-5. DOI: 10.1093/infdis/145.2.200. View

15.

Lammert J . Cytotoxic cells induced after Chlamydia psittaci infection in mice. Infect Immun. 1982; 35(3):1011-7. PMC: 351148. DOI: 10.1128/iai.35.3.1011-1017.1982. View

16.

Caldwell H, Perry L . Neutralization of Chlamydia trachomatis infectivity with antibodies to the major outer membrane protein. Infect Immun. 1982; 38(2):745-54. PMC: 347801. DOI: 10.1128/iai.38.2.745-754.1982. View

17.

Rank R, Barron A . Humoral immune response in acquired immunity to chlamydial genital infection of female guinea pigs. Infect Immun. 1983; 39(1):463-5. PMC: 347964. DOI: 10.1128/iai.39.1.463-465.1983. View

18.

Williams D, Schachter J, Coalson J, Grubbs B . Cellular immunity to the mouse pneumonitis agent. J Infect Dis. 1984; 149(4):630-9. DOI: 10.1093/infdis/149.4.630. View