Antigen-reactive T Cells Can Be Activated Buy Autologous Macrophages in the Absence of Added Antigen

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1981 Feb 1

PMID 6453920

Citations 10

Authors

P B Hausman

D P Stites

J D Stobo

Affiliations

Soon will be listed here.

Abstract

T cells responsive to macrophages (M phi) in the autologous mixed lymphocyte reaction (AMLR) contain those cells that can be induced to proliferate by soluble antigens. Negative solution (5-bromo-2-deoxyuridine and light) of T cells activated by autologous M phi also removed those cells required for reactivity to Candida albicans and purified protein derivative. Positive selection of T cells responsive to autologous M phi yields a population that is simultaneously enriched in antigen reactivity. Some patients demonstrating cutaneous anergy and diminished in vitro blast transformation in response to soluble antigen also lack T cells responsive to the AMLR to M phi. When considered in conjunction with previously reported data, these findings indicate the AMLR occurring between T cells and M phi in the absence of soluble antigen represents self recognition occurring between antigen-reactive T cells and antigen-presenting M phi.

Citing Articles

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Zubler R, Kanagawa O J Exp Med. 1982; 156(2):415-29.

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T-cell macrophage subset interactions and decreased autologous mixed lymphocyte reaction in Sjögren's syndrome.

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