Selective Induction of an Immune Response in Human External Secretions by Ingestion of Bacterial Antigen

Overview

Journal J Clin Invest

Specialty General Medicine

Date 1978 Mar 1

PMID 641151

Citations 67

Authors

J Mestecky

J R McGhee

R R Arnold

S M Michalek

S J Prince

J L Babb

Affiliations

Soon will be listed here.

Abstract

Ingestion of capsules which contained killed Streptococcus mutans by four healthy human subjects led to the appearance of specific antibodies in external secretions. Salivary and lacrymal antibodies were detected within 1 wk of ingestion and continued to increase throughout a 14-day immunization period, with a gradual decline during the 2 ensuing months. A second period of immunization resulted in a pronounced increase of specific antibody levels which occurred earlier than in the primary immunization period and reached peak levels by day 10. No change was detected in serum antibody levels throughout either immunization period. The antibody activity in all secretions was associated with the immunoglobulin A class, as determined by immunochemical analyses. These data indicate that ingestion of bacterial antigens selectively stimulates the immune response in secretions.

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References

LOWRY O, ROSEBROUGH N, FARR A, RANDALL R . Protein measurement with the Folin phenol reagent. J Biol Chem. 1951; 193(1):265-75. View

Cebra J, Gearhart P, Kamat R, Robertson S, Tseng J . Origin and differentiation of lymphocytes involved in the secretory IgA responses. Cold Spring Harb Symp Quant Biol. 1977; 41 Pt 1:201-15. DOI: 10.1101/sqb.1977.041.01.026. View

McWilliams M, Lamm M . Mesenteric lymph node B lymphoblasts which home to the small intestine are precommitted to IgA synthesis. J Exp Med. 1977; 145(4):866-75. PMC: 2180636. DOI: 10.1084/jem.145.4.866. View

Schaeffer M, Rhodes M, Prince S, Michalek S, McGhee J . A plastic intraoral device for the collection of human parotid saliva. J Dent Res. 1977; 56(7):728-33. DOI: 10.1177/00220345770560070401. View

Shvartsman Y, Agranovskaya E, ZYKOV M . Formation of secretory and circulating antibodies after immunization with live and inactivated influenza virus vaccines. J Infect Dis. 1977; 135(5):697-705. DOI: 10.1093/infdis/135.5.697. View

Brandtzaeg P, TOLO K . Mucosal penetrability enhanced by serum-derived antibodies. Nature. 1977; 266(5599):262-3. DOI: 10.1038/266262a0. View

SELIGMANN M . Membrane cell markers in human leukemias and lymphomas. Ric Clin Lab. 1976; 6(2):93-8. DOI: 10.1007/BF02949079. View

Arnold R, Mestecky J, McGhee J . Naturally occurring secretory immunoglobulin A antibodies to Streptococcus mutans in human colostrum and saliva. Infect Immun. 1976; 14(2):355-62. PMC: 420890. DOI: 10.1128/iai.14.2.355-362.1976. View

Montgomery P, Cohn J, Lally E . The induction and characterization of secretory IgA antibodies. Adv Exp Med Biol. 1974; 45(0):453-62. DOI: 10.1007/978-1-4613-4550-3_54. View

10.

Cooper M, Kincade P, Bockman D, Lawton A . Origin, distribution and differentiation of IgA-producing cells. Adv Exp Med Biol. 1974; 45(0):13-22. DOI: 10.1007/978-1-4613-4550-3_2. View

11.

Mestecky J, KRAUS F, Voight S . Proportion of human colostral immunoglobulin-A molecules containing the secretory determinant. Immunology. 1970; 18(2):237-43. PMC: 1455549. View

12.

Ogra P, Wallace R, Umana G, Ogra S, Grant D, Morag A . Implications of secretory immune system in viral infections. Adv Exp Med Biol. 1974; 45(0):271-82. DOI: 10.1007/978-1-4613-4550-3_33. View

13.

Waldman R, Ganguly R . The role of the secretory immune system in protection against agents which infect the respiratory tract. Adv Exp Med Biol. 1974; 45(0):283-94. DOI: 10.1007/978-1-4613-4550-3_34. View

14.

Taubman M, Genco R . Induction and properties of rabbit secretory A antibody directed to group A streptococcal carbohydrate. Immunochemistry. 1971; 8(12):1137-55. DOI: 10.1016/0019-2791(71)90392-2. View

15.

Mestecky J, Kulhavy R, KRAUS F . Studies on human secretory immunoglobulin A. II. Subunit structure. J Immunol. 1972; 108(3):738-47. View

16.

Genco R, Taubman M . Secretory gamma-A antibodies induced by local immunization. Nature. 1969; 221(5181):679-81. DOI: 10.1038/221679a0. View

17.

Griscelli C, Vassalli P . The gut-associated lymphoid system: nature and properties of the large dividing cells. Eur J Immunol. 1974; 4(6):435-43. DOI: 10.1002/eji.1830040610. View

18.

Ganguly R, Ogra P, REGAS S, Waldman R . Rubella immunization of volunteers via the respiratory tract. Infect Immun. 1973; 8(4):497-502. PMC: 422882. DOI: 10.1128/iai.8.4.497-502.1973. View

19.

PERCH B, KJEMS E, Ravn T . Biochemical and serological properties of Streptococcus mutans from various human and animal sources. Acta Pathol Microbiol Scand B Microbiol Immunol. 1974; 82(3):357-70. DOI: 10.1111/j.1699-0463.1974.tb02338.x. View

20.

BOHL E, Saif L, Gupta R, Frederick G . Secretory antibodies in milk of swine against transmissible gastroenteritis virus. Adv Exp Med Biol. 1974; 45(0):337-42. DOI: 10.1007/978-1-4613-4550-3_40. View