J Mestecky
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Explore the profile of J Mestecky including associated specialties, affiliations and a list of published articles.
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314
Citations
5971
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Recent Articles
1.
Kutzler M, Wise M, Hutnick N, Moldoveanu Z, Hunter M, Reuter M, et al.
Mucosal Immunol
. 2015 May;
9(1):13-23.
PMID: 25943275
There have been encouraging results for the development of an effective HIV vaccine. However, many questions remain regarding the quality of immune responses and the role of mucosal antibodies. We...
2.
Kantele A, Hakkinen M, Zivny J, Elson C, Mestecky J, Kantele J
Clin Dev Immunol
. 2011 Jul;
2011:614383.
PMID: 21716728
Keyhole limpet haemocyanin (KLH) appears to be a promising protein carrier for tumor antigens in numerous cancer vaccine candidates. The humoral immune response to KLH was characterized at the single-cell...
3.
Matousovic K, Mestecky J, Tomana M, Novak J
Vnitr Lek
. 2008 Jun;
54(3):239-44.
PMID: 18522291
IgA nephropathy is the most common cause of chronic renal failure among primary glomerulonephritides. During the last decade, there was a remarkable progress in understanding its pathogenesis. A number of...
4.
Mestecky J, Tomana M, Moldoveanu Z, Julian B, Suzuki H, Matousovic K, et al.
Kidney Blood Press Res
. 2008 Jan;
31(1):29-37.
PMID: 18182777
Studies of the properties of immune complexes (IC) in the circulation, urine, and mesangium of IgA nephropathy (IgAN) patients have provided data relevant to the pathogenesis of this disease. IC...
5.
Moldoveanu Z, Wyatt R, Lee J, Tomana M, Julian B, Mestecky J, et al.
Kidney Int
. 2007 Mar;
71(11):1148-54.
PMID: 17342176
Immunoglobulin A (IgA) nephropathy is the most prevalent form of glomerulonephritis worldwide. A renal biopsy is required for an accurate diagnosis, as no convenient biomarker is currently available. We developed...
6.
Matousovic K, Mestecky J, Tomana M, Novak J
Vnitr Lek
. 2006 May;
52(3):256-62.
PMID: 16722157
Immunoglobulin A (IgA) is a dominant immunoglobulin of the mucosal surfaces, but it is also present in plasma. In men and in hominoid primates it occurs in two subclasses: IgA1...
7.
Novak J, Tomana M, Shah G, Brown R, Mestecky J
J Dent Res
. 2005 Sep;
84(10):897-901.
PMID: 16183787
Periodontal disease is a chronic inflammatory disease of bacterial etiology. In many other chronic inflammatory diseases, IgG glycans are galactose-deficient and thus capable of complement activation through the lectin pathway....
8.
Tlaskalova-Hogenova H, Tuckova L, Mestecky J, Kolinska J, Rossmann P, Stepankova R, et al.
Scand J Immunol
. 2005 Jun;
62 Suppl 1:106-13.
PMID: 15953193
Organisms live in continuos interaction with their environment; this interaction is of vital importance but at the same time can be life threatening. The largest and most important interface between...
9.
Matousovic K, Konecny K, Mestecky J, Tomana M, Novak J
Cas Lek Cesk
. 2003 Mar;
141(23):729-34.
PMID: 12650029
Human immunoglobulin A is represented by two structurally and functionally distinct subclasses: IgA1 and IgA2. IgA1, which is almost exclusively present in the mesangial deposits in IgA nephropathy patients, contains...
10.
Mestecky J
Adv Exp Med Biol
. 2002 Jan;
501:197-205.
PMID: 11787683
External secretions, including milk, contain large amounts of immunoglobulins (Ig) and innate factors of humoral immunity The Ig isotype distribution, their origin, transport, and absorbability from the gut lumen differ...