Compared Myocardial and Vascular Effects of Captopril and Dihydralazine During Hypertension Development in Spontaneously Hypertensive Rats

Overview

Journal Br J Pharmacol

Publisher Wiley

Specialty Pharmacology

Date 1983 Nov 1

PMID 6357337

Citations 16

Authors

J L Freslon

J F Giudicelli

Affiliations

Soon will be listed here.

Abstract

When administered to young spontaneously hypertensive rats (SHRs), dihydralazine (25 mg kg-1, daily) and captopril (100 mg kg-1, daily) prevent with the same efficacy genetic hypertension development (GHD). Dihydralazine treatment increased vascular mesenteric compliance, as shown by a significant decrease in the stiffness of the vessels (-27%), and induced slight reductions in contractility (-12%) and in wall to lumen (W/L) ratio (-15%). After treatment withdrawal, all these parameters returned to control values within 7 weeks, as did blood pressure. Captopril treatment also strongly increased the mesenteric vessels compliance, vessel stiffness being decreased by 16%, and reduced their contractility (-15%) and their W/L ratio (-30%). These effects as well as those exerted on blood pressure persisted up to 7 weeks after treatment ceased although there was a slight trend to a progressive reduction in the intensity of both phenomena. These experiments show that captopril but not dihydralazine has a long-lasting effect in opposing the functional and morphological vascular alterations occurring during GHD in SHRs and this phenomenon probably contributes to a large extent to the sustained preventive effects of the drug against GHD.

Citing Articles

Testing the Translational Power of the Zebrafish: An Interspecies Analysis of Responses to Cardiovascular Drugs.

Margiotta-Casaluci L, Owen S, Rand-Weaver M, Winter M Front Pharmacol. 2019; 10:893.

PMID: 31474857 PMC: 6707810. DOI: 10.3389/fphar.2019.00893.

Hypoxia/Reoxygenation of Rat Renal Arteries Impairs Vasorelaxation via Modulation of Endothelium-Independent sGC/cGMP/PKG Signaling.

Braun D, Zollbrecht C, Dietze S, Schubert R, Golz S, Summer H Front Physiol. 2018; 9:480.

PMID: 29773995 PMC: 5943512. DOI: 10.3389/fphys.2018.00480.

Hemodynamic, morphometric and autonomic patterns in hypertensive rats - Renin-Angiotensin system modulation.

Zamo F, Lacchini S, Mostarda C, Chiavegatto S, Silva I, Oliveira E Clinics (Sao Paulo). 2010; 65(1):85-92.

PMID: 20126350 PMC: 2815287. DOI: 10.1590/S1807-59322010000100013.

Bradykinin (B2) independent effect of captopril on the development of pressure overload cardiac hypertrophy.

Turcani M, Rupp H Mol Cell Biochem. 2000; 212(1-2):219-25.

PMID: 11108154

The effects of anti-hypertensive therapy on the structural, mechanical and metabolic properties of the rat aorta.

Clark J, Radda G, Boehm E J Muscle Res Cell Motil. 2000; 21(3):255-67.

PMID: 10952173 DOI: 10.1023/a:1005646614308.

References

Swales J . Arterial wall or plasma renin in hypertension?. Clin Sci (Lond). 1979; 56(4):293-8. DOI: 10.1042/cs0560293. View

GARST J, KOLETSKY S, WISENBAUGH P, Hadady M, Matthews D . Arterial wall renin and renal venous renin in the hypertensive rat. Clin Sci (Lond). 1979; 56(1):41-6. DOI: 10.1042/cs0560041. View

Frohlich E, TARAZI R . Is arterial pressure the sole factor responsible for hypertensive cardiac hypertrophy?. Am J Cardiol. 1979; 44(5):959-63. DOI: 10.1016/0002-9149(79)90229-7. View

Okuno T, Kondo K, Konishi K, Saruta T, Kato E . SQ 14,225 attenuates the vascular response to norepinephrine in the rat mesenteric arteries. Life Sci. 1979; 25(15):1343-9. DOI: 10.1016/0024-3205(79)90401-6. View

Ferrone R, Antonaccio M . Prevention of the development of spontaneous hypertension in rats by captopril (SQ 14,225). Eur J Pharmacol. 1979; 60(2-3):131-7. DOI: 10.1016/0014-2999(79)90211-5. View

Antonaccio M, Rubin B, Horovitz Z, LAFFAN R, Goldberg M, High J . Effects of chronic treatment with captopril (SQ 14,225), an orally active inhibitor of angiotensin I-converting enzyme, in spontaneously hypertensive rats. Jpn J Pharmacol. 1979; 29(2):285-94. DOI: 10.1254/jjp.29.285. View

Thurston H, Swales J, Bing R, Hurst B, MARKS E . Vascular renin-like activity and blood pressure maintenance in the rat. Studies of the effect of changes in sodium balance, hypertension and nephrectomy. Hypertension. 1979; 1(6):643-9. DOI: 10.1161/01.hyp.1.6.643. View

Sen S, TARAZI R, BUMPUS F . Effect of converting enzyme inhibitor (SQ14,225) on myocardial hypertrophy in spontaneously hypertensive rats. Hypertension. 1980; 2(2):169-76. DOI: 10.1161/01.hyp.2.2.169. View

Koike H, Ito K, Miyamoto M, Nishino H . Effects of long-term blockade of angiotensin converting enzyme with captopril (SQ14,225) on hemodynamics and circulating blood volume in SHR. Hypertension. 1980; 2(3):299-303. DOI: 10.1161/01.hyp.2.3.299. View

10.

Hart M, Heistad D, BRODY M . Effect of chronic hypertension and sympathetic denervation on wall/lumen ratio of cerebral vessels. Hypertension. 1980; 2(4):419-23. DOI: 10.1161/01.hyp.2.4.419. View

11.

Ferrone R, Heran C, Antonaccio M . Comparison of the acute and chronic hemodynamic effects of captopril and guanethidine in spontaneously hypertensive rats. Clin Exp Hypertens (1978). 1980; 2(2):247-72. DOI: 10.3109/10641968009046423. View

12.

Greeberg S . Studies on the effect of chronic oral administration of minoxidil and hydralazine on vascular function in spontaneously hypertensive rats. J Pharmacol Exp Ther. 1980; 215(2):279-86. View

13.

Giudicelli J, Freslon J, Glasson S, Richer C . Captopril and hypertension development in the SHR. Clin Exp Hypertens (1978). 1980; 2(6):1083-96. DOI: 10.3109/10641968009037162. View

14.

Casellas D, Mimran A, Dupont M, Chevillard C . Attenuation by SQ 14,255 (captopril) of the vascular response to noradrenaline in the rate isolated kidney. Br J Clin Pharmacol. 1980; 10(6):621-3. PMC: 1430226. DOI: 10.1111/j.1365-2125.1980.tb00521.x. View

15.

Seidel C, Allen J, Bowers R . Mechanical and biochemical alterations of aorta induced by hydralazine hypotension. J Pharmacol Exp Ther. 1980; 213(3):514-9. View

16.

Spertini F, Brunner H, Waeber B, Gavras H . The opposing effects of chronic angiotensin-converting enzyme blockade by captopril on the responses to exogenous angiotensin II and vasopressin vs. norepinephrine in rats. Circ Res. 1981; 48(5):612-8. DOI: 10.1161/01.res.48.5.612. View

17.

Sinaiko A . Influence of adrenergic nervous system on vasodilator-induced renin release in the conscious rat. Proc Soc Exp Biol Med. 1981; 167(1):25-9. DOI: 10.3181/00379727-167-41119. View

18.

Collis M, Keddie J . Captopril attenuates adrenergic vasoconstriction in rat mesenteric arteries by angiotensin-dependent and -independent mechanisms. Clin Sci (Lond). 1981; 61(3):281-6. DOI: 10.1042/cs0610281. View

19.

Antonaccio M, Rubin B, Kotler D . Effects of captopril on vascular reactivity of SHR in vivo and in vitro. Hypertension. 1981; 3(6 Pt 2):II-211-5. DOI: 10.1161/01.hyp.3.6_pt_2.ii-211. View

20.

Cohen M, Kurz K . Angiotensin converting enzyme inhibition in tissues from spontaneously hypertensive rats after treatment with captopril or MK-421. J Pharmacol Exp Ther. 1982; 220(1):63-9. View