Angiotensin Converting Enzyme Inhibition and Vascular Hypertrophy in Hypertension

Overview

Journal Cardiovasc Drugs Ther

Specialties Cardiology & Vascular Diseases
Pharmacology

Date 1990 Feb 1

PMID 2285616

Citations 5

Authors

G H Gibbons

V J Dzau

Affiliations

Soon will be listed here.

Abstract

The pathogenesis of hypertension is associated with a remodeling of vascular structure. Follow has postulated that the decreased luminal area and thickened medial layer in hypertensive vessels enhances the vasoconstrictive response to vasoactive agents. It is hypothesized that this increase in vascular reactivity may serve to perpetuate hypertension. A growing body of evidence suggests that autocrine-paracrine vasoactive substances and growth factors modulate vascular structure in hypertension. We speculate that therapeutic interventions that normalize blood pressure as well as reverse the vascular remodeling process may have special clinical value. The role of the paracrine renin-angiotensin system and angiotensin converting enzyme inhibitors in hypertension is discussed in this context.

Citing Articles

Dynamics of Vascular Remodeling: An Overview and Bibliography.

Bortman , Losordo J Thromb Thrombolysis. 1996; 3(1):71-86.

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The renin-angiotensin system and coronary vasomotion.

Ertl G, Hu K, Bauer W, Bauer B Heart. 1996; 76(3 Suppl 3):45-52.

PMID: 8977364 PMC: 484488. DOI: 10.1136/hrt.76.3_suppl_3.45.

Endothelial control of vascular and myocardial function in heart failure.

Paulus W Cardiovasc Drugs Ther. 1994; 8(3):437-46.

PMID: 7947359 DOI: 10.1007/BF00877920.

Angiotensin converting enzyme inhibitors in angina and myocardial infarction. What role will they play in the 1990s?.

Ertl G Drugs. 1993; 46(2):209-18.

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Angiotensin II induces delayed mitogenesis and cellular proliferation in rat aortic smooth muscle cells. Correlation with the expression of specific endogenous growth factors and reversal by suramin.

Weber H, Taylor D, Molloy C J Clin Invest. 1994; 93(2):788-98.

PMID: 7509348 PMC: 293930. DOI: 10.1172/JCI117033.

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