Transforming Potential of a Human Protooncogene (c-fps/fes) Locus

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1984 May 1

PMID 6328490

Citations 11

Authors

J G Sodroski

W C Goh

W A Haseltine

Affiliations

Soon will be listed here.

Abstract

The protooncogene c-fps/fes is a single vertebrate locus homologous to both the fps transforming gene of Fujinami avian sarcoma virus and the fes transforming gene of two feline sarcoma virus isolates. The human c-fps/fes locus has been previously cloned and characterized. We report that a recombinant gene in which 3' human c-fps/fes sequences replace over 80% of the feline sarcoma virus fes sequences transforms NIH 3T3 mouse fibroblasts and encodes a protein kinase. Cells transformed by this recombinant possess increased phosphotyrosine levels. These observations demonstrate that a large carboxyl portion of a human c-fps/fes protein product can functionally complement a retroviral transforming protein.

Citing Articles

Identification of ALV-J associated acutely transforming virus Fu-J carrying complete v-fps oncogene.

Wang Y, Li J, Li Y, Fang L, Sun X, Chang S Virus Genes. 2016; 52(3):365-71.

PMID: 27108997 DOI: 10.1007/s11262-016-1301-6.

The Fps/Fes protein-tyrosine kinase promotes angiogenesis in transgenic mice.

Greer P, Haigh J, Mbamalu G, Khoo W, Bernstein A, Pawson T Mol Cell Biol. 1994; 14(10):6755-63.

PMID: 7523858 PMC: 359206. DOI: 10.1128/mcb.14.10.6755-6763.1994.

Cellular localization of c-fps gene product NCP98.

Young J, Martin G J Virol. 1984; 52(3):913-8.

PMID: 6092720 PMC: 254613. DOI: 10.1128/JVI.52.3.913-918.1984.

Characterization of human c-fes/fps reveals a new transcription unit (fur) in the immediately upstream region of the proto-oncogene.

Roebroek A, Schalken J, Bussemakers M, Van Heerikhuizen H, Onnekink C, Debruyne F Mol Biol Rep. 1986; 11(2):117-25.

PMID: 3488499 DOI: 10.1007/BF00364823.

Induction of proliferation of neuroretina cells by long terminal repeat activation of the carboxy-terminal part of c-mil.

Dozier C, Denhez F, Coll J, Amouyel P, Quatannens B, Begue A Mol Cell Biol. 1987; 7(5):1995-8.

PMID: 3299058 PMC: 365308. DOI: 10.1128/mcb.7.5.1995-1998.1987.

References

Graham F, Van Der Eb A . A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology. 1973; 52(2):456-67. DOI: 10.1016/0042-6822(73)90341-3. View

Aviv H, Leder P . Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose. Proc Natl Acad Sci U S A. 1972; 69(6):1408-12. PMC: 426713. DOI: 10.1073/pnas.69.6.1408. View

Southern E . Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol. 1975; 98(3):503-17. DOI: 10.1016/s0022-2836(75)80083-0. View

Maxam A, Gilbert W . A new method for sequencing DNA. Proc Natl Acad Sci U S A. 1977; 74(2):560-4. PMC: 392330. DOI: 10.1073/pnas.74.2.560. View

SANGER F, Nicklen S, Coulson A . DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A. 1977; 74(12):5463-7. PMC: 431765. DOI: 10.1073/pnas.74.12.5463. View

Reddy V, Thimmappaya B, Dhar R, Subramanian K, Zain B, Pan J . The genome of simian virus 40. Science. 1978; 200(4341):494-502. DOI: 10.1126/science.205947. View

Hunter T, Sefton B . Transforming gene product of Rous sarcoma virus phosphorylates tyrosine. Proc Natl Acad Sci U S A. 1980; 77(3):1311-5. PMC: 348484. DOI: 10.1073/pnas.77.3.1311. View

Reynolds Jr F, Van de Ven W, Stephenson J . Feline sarcoma virus P115-associated protein kinase phosphorylates tyrosine. Identification of a cellular substrate conserved during evolution. J Biol Chem. 1980; 255(22):11040-7. View

Thomas P . Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. Proc Natl Acad Sci U S A. 1980; 77(9):5201-5. PMC: 350025. DOI: 10.1073/pnas.77.9.5201. View

10.

Feldman R, Hanafusa T, Hanafusa H . Characterization of protein kinase activity associated with the transforming gene product of Fujinami sarcoma virus. Cell. 1980; 22(3):757-65. DOI: 10.1016/0092-8674(80)90552-8. View

11.

Pawson T, Guyden J, KUNG T, Radke K, Gilmore T, Martin G . A strain of Fujinami sarcoma virus which is temperature-sensitive in protein phosphorylation and cellular transformation. Cell. 1980; 22(3):767-75. DOI: 10.1016/0092-8674(80)90553-x. View

12.

Hanafusa T, Mathey-Prevot B, Feldman R, Hanafusa H . Mutants of Fujinami sarcoma virus which are temperature sensitive for cellular transformation and protein kinase activity. J Virol. 1981; 38(1):347-55. PMC: 171157. DOI: 10.1128/JVI.38.1.347-355.1981. View

13.

Mulligan R, Berg P . Selection for animal cells that express the Escherichia coli gene coding for xanthine-guanine phosphoribosyltransferase. Proc Natl Acad Sci U S A. 1981; 78(4):2072-6. PMC: 319285. DOI: 10.1073/pnas.78.4.2072. View

14.

Rosenberg Z, Sahagan B, Worley M, Essex M, Haseltine W . Transformation with subgenomic fragments of feline sarcoma virus proviral DNA. Virology. 1981; 112(2):496-504. DOI: 10.1016/0042-6822(81)90297-x. View

15.

Fedele L, Even J, Garon C, DONNER L, Sherr C . Recombinant bacteriophages containing the integrated transforming provirus of Gardner--Arnstein feline sarcoma virus. Proc Natl Acad Sci U S A. 1981; 78(7):4036-40. PMC: 319720. DOI: 10.1073/pnas.78.7.4036. View

16.

Trus M, Sodroski J, Haseltine W . Isolation and characterization of a human locus homologous to the transforming gene (v-fes) of feline sarcoma virus. J Biol Chem. 1982; 257(6):2730-3. View

17.

Patschinsky T, Hunter T, Esch F, Cooper J, Sefton B . Analysis of the sequence of amino acids surrounding sites of tyrosine phosphorylation. Proc Natl Acad Sci U S A. 1982; 79(4):973-7. PMC: 345881. DOI: 10.1073/pnas.79.4.973. View

18.

Groffen J, Heisterkamp N, Grosveld F, Van de Ven W, Stephenson J . Isolation of human oncogene sequences (v-fes homolog) from a cosmid library. Science. 1982; 216(4550):1136-8. DOI: 10.1126/science.6281890. View

19.

Gallo R, Wong-Staal F . Retroviruses as etiologic agents of some animal and human leukemias and lymphomas and as tools for elucidating the molecular mechanism of leukemogenesis. Blood. 1982; 60(3):545-57. View

20.

Franchini G, Gelmann E, Dalla-Favera R, Gallo R, Wong-Staal F . Human gene (c-fes) related to the onc sequences of Snyder-Theilen feline sarcoma virus. Mol Cell Biol. 1982; 2(8):1014-9. PMC: 369889. DOI: 10.1128/mcb.2.8.1014-1019.1982. View