Transcripts of Human HLA Gene Fragments Lacking the 5'-terminal Region in Transfected Mouse Cells

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1984 Feb 1

PMID 6322158

Citations 15

Authors

O Yoshie

H Schmidt

P Lengyel

E S Reddy

W R Morgan

S M Weissman

Affiliations

Soon will be listed here.

Abstract

Clones of mouse L cells transfected with a human HLA-B7 gene fragment lacking the 5' segment of exon 2 and all upstream sequences express HLA-specific transcripts of various lengths. These include species that correspond in size to full-length HLA-B7 mRNA. The level of these transcripts is increased in cells treated with interferon. It is probable that the full-length transcripts arise as a result of the linkage of the HLA-B7 gene fragments with DNA segments providing transcription initiation or polyadenylylation signals.

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