Mouse Interferons Enhance the Accumulation of a Human HLA RNA and Protein in Transfected Mouse and Hamster Cells

Overview

Journal J Biol Chem

Specialty Biochemistry

Date 1982 Nov 25

PMID 6183260

Citations 17

Authors

O Yoshie

H Schmidt

E S Reddy

S Weissman

P Lengyel

Affiliations

Soon will be listed here.

Abstract

A recombinant clone (pJY150R1.1) encoding the human major histocompatibility antigen (HLA-B7) was introduced into mouse cells and hamster cells by cotransformation with selectable genes. The exposure to mouse interferon of the cells transformed to HLA-B7+ resulted in a severalfold increase in the level of HLA antigen and RNA. The HLA-B7 clone used for the transfection includes a 670-base pair DNA sequence upstream from the coding segment. It remains to be established if the 670-base pair segment is necessary and/or sufficient to make the transcription of the HLA gene responsive to interferon.

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