Conservation and Divergence of Immunoglobulin VH Pseudogenes

Overview

Journal EMBO J

Specialties Biotechnology
Molecular Biology

Date 1983 Jan 1

PMID 6315403

Citations 14

Authors

J B Cohen

D Givol

Affiliations

Soon will be listed here.

Abstract

The 12 immunoglobulin VH pseudogenes, that have been characterized to date, differ from most pseudogenes of other multigene families in two aspects: (i) they carry only one (11 cases) or at the most two (1 case) deleterious mutations and (ii) they show no evidence of increased divergence from intact VH genes. We describe here the first immunoglobulin VH pseudogene that does not have these characteristics. This pseudogene accumulated numerous deleterious mutations and diverged considerably from other genes of the VH gene family to which it belongs. In possible contrast to the other VH pseudogenes, this pseudogene seems to be selectively neutral. We discuss the implications of the characterization of this diverged VH pseudogene in relation to our understanding of the genetic mechanisms that generate diversity among germline immunoglobulin VH genes.

Citing Articles

Characterization of a V kappa family in Mus musculus castaneus: sequence analysis.

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Germ line maintenance of the pseudogene donor pool for somatic immunoglobulin gene conversion in chickens.

McCormack W, Hurley E, Thompson C Mol Cell Biol. 1993; 13(2):821-30.

PMID: 8423804 PMC: 358965. DOI: 10.1128/mcb.13.2.821-830.1993.

Immunoglobulin genes of different subgroups are interdigitated within the VK locus.

Pech M, Zachau H Nucleic Acids Res. 1984; 12(24):9229-36.

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Allelic immunoglobulin VH genes in two mouse strains: possible germline gene recombination.

Cohen J, Givol D EMBO J. 1983; 2(11):2013-8.

PMID: 6416826 PMC: 555402. DOI: 10.1002/j.1460-2075.1983.tb01693.x.

Polymorphisms of a human variable heavy chain gene show linkage with constant heavy chain genes.

Johnson M, Natali A, Cann H, Honjo T, Cavalli-Sforza L Proc Natl Acad Sci U S A. 1984; 81(24):7840-4.

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