Evolution of Pseudogenes in the Immunoglobulin VH-gene Family of the Mouse

Overview

Journal Immunogenetics

Specialties Allergy & Immunology
Genetics

Date 1987 Jan 1

PMID 2820872

Citations 14

Authors

T Blankenstein

F Bonhomme

U Krawinkel

Affiliations

Soon will be listed here.

Abstract

A quantitative analysis of the complexity of the J558 VH-gene family in the mouse immunoglobulin heavy chain (Igh) gene locus has been performed. Considerable variations in the degree of complexity are observed in various Igh haplotypes derived from laboratory mice and wild mice. The BALB/c strain shows the highest degree of complexity of the J558 VH-gene family when all mice are compared. Multiple gene duplications seem to have occurred in the BALB/c-derived J558 VH-gene family less than 1-2 million years ago. This dating is supported by the divergence in coding and flanking regions of three strongly homologous VH-region genes. Two of these genes were generated by the duplication of a pseudogene about 1.5 X 10(5) years ago. A recent expansion of the J558 VH-gene family and therefore little time for evolutionary drift may explain why most of the pseudogenes in this family exhibit a largely intact structure. We also describe two VH-region genes which represent older pseudogenes in states of progressive disintegration.

Citing Articles

Characterization of a V kappa family in Mus musculus castaneus: sequence analysis.

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Germ line maintenance of the pseudogene donor pool for somatic immunoglobulin gene conversion in chickens.

McCormack W, Hurley E, Thompson C Mol Cell Biol. 1993; 13(2):821-30.

PMID: 8423804 PMC: 358965. DOI: 10.1128/mcb.13.2.821-830.1993.

Conservation of sequence in recombination signal sequence spacers.

Ramsden D, Baetz K, Wu G Nucleic Acids Res. 1994; 22(10):1785-96.

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Content and organization of the human Ig VH locus: definition of three new VH families and linkage to the Ig CH locus.

Berman J, Mellis S, Pollock R, Smith C, Suh H, Heinke B EMBO J. 1988; 7(3):727-38.

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Germline antibody V regions as determinants of clonal persistence and malignant growth in the B cell compartment.

Forster I, Gu H, Rajewsky K EMBO J. 1988; 7(12):3693-703.

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