The Superoxide Free Radical: Its Biochemistry and Pathophysiology

Overview

Journal Surgery

Specialty General Surgery

Date 1983 Sep 1

PMID 6310808

Citations 20

Authors

J M McCord

Affiliations

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Abstract

The partial reduction of molecular oxygen in biologic systems produces the cytotoxic intermediates superoxide, hydrogen peroxide, and hydroxyl radical. The superoxide radical is now recognized to play significant roles in a number of pathophysiologic states including oxygen toxicity, radiation damage, phagocyte-mediated inflammation, and postischemic injury.

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