Complete Nucleotide Sequence of the Haemagglutinin Gene from a Human Influenza Virus of the Hong Kong Subtype

Overview

Journal Nucleic Acids Res

Publisher Oxford University Press

Specialty Biochemistry

Date 1980 Jun 25

PMID 6253883

Citations 18

Authors

G W Both

M J Sleigh

Affiliations

Soon will be listed here.

Abstract

The complete nucleotide sequence has been determined for a cloned double-stranded DNA copy of the haemagglutinin gene from the human influenza strain A/NT/60/68/29C, a laboratory-isolated variant of A/NT/60/68, an early strain of the Hong Kong subtype. The gene is 1765 nucleotides long and contains information sufficient to code for a protein of 566 amino acids, which includes a hydrophobic leader peptide (16 residues), HA1 (328), HA2 (221) and an arginine residue which joins the HA subunits. Comparison of the predicted amino acid sequence for 29C haemagglutinin with protein sequence data available for HA from other influenza strains shows that no potential coding information is lost by processing of the mRNA. A comparison of the amino acid sequences predicted from the gene sequences for 29C and fowl plague virus haemagglutinins, (1) indicates the extent to which changes can occur in the primary sequence of different regions of the protein, while maintaining essential structure and function.

Citing Articles

Hierarchical analysis of influenza A hemagglutinin gene sequences.

Lipman D, Smith T, Beckman R, Waterman M Nucleic Acids Res. 1982; 10(17):5375-89.

PMID: 7145705 PMC: 320879. DOI: 10.1093/nar/10.17.5375.

The complete sequence of RNA segment 2 of influenza A/NT/60/68 P1 protein.

Bishop D, HUDDLESTON J, Brownlee G Nucleic Acids Res. 1982; 10(4):1335-43.

PMID: 7041090 PMC: 320529. DOI: 10.1093/nar/10.4.1335.

Evolution of influenza A and B viruses: conservation of structural features in the hemagglutinin genes.

Krystal M, Elliott R, Benz Jr E, Young J, Palese P Proc Natl Acad Sci U S A. 1982; 79(15):4800-4.

PMID: 6956892 PMC: 346766. DOI: 10.1073/pnas.79.15.4800.

The sequence of RNA segment 1 of influenza virus A/NT/60/68 and its comparison with the corresponding segment of strains A/PR/8/34 and A/WSN/33.

Jones K, HUDDLESTON J, Brownlee G Nucleic Acids Res. 1983; 11(5):1555-66.

PMID: 6828387 PMC: 325815. DOI: 10.1093/nar/11.5.1555.

REISNER A, Bucholtz C EMBO J. 1983; 2(7):1145-9.

PMID: 6628365 PMC: 555248. DOI: 10.1002/j.1460-2075.1983.tb01559.x.

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