Evidence for the Common Origin of Viral and Cellular Sequences Involved in Sarcomagenic Transformation

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1980 Jul 1

PMID 6251277

Citations 15

Authors

L H Wang

P Snyder

T Hanafusa

H Hanafusa

Affiliations

Soon will be listed here.

Abstract

The src genes of six different strains of avian sarcoma virus (ASV) were compared with those of a series of newly isolated sarcoma viruses, termed "recovery avian sarcoma viruses" (rASV's). The rASV's were isolated recently from chicken and quail tumors induced by transformation-defective (td) deletion mutants of Schmidt-Ruppin Rous sarcoma virus. The RNase T1-resistant oligonucleotide maps were constructed for the RNA genomes of different strains of ASV and td mutants. The src-specific sequences, characterized by RNase T1-resistant oligonucleotides ranging from 9 to 19 nucleotides long, were defined as those mapping between approximately 600 and 2,800 nucleotides from the 3' polyadenylate end of individual sarcoma viral RNAs, and missing in the corresponding td viral RNAs. Our results revealed that 12 src-specific oligonucleotides were highly conserved among several strains of ASV, including the rASV's, whereas certain strains of ASV were found to contain one to three characteristic src-specific oligonucleotides. We previously presented evidence supporting the idea that most of the src-specific sequences present in rASV RNAs are derived from cellular genetic information. Our present data indicate that the src genes of rASV's are closely related to other known ASVs. We conclude that the src genes of different strains of ASV and the cellular sarc sequences are of common origin, although some divergence has occurred among different viral src genes and related cellular sequences.

Citing Articles

The U3 region of the long terminal repeat of a subgroup A transformation-defective rous sarcoma virus (tdPH2010) converts a noncytopathic virus to a cytopathic virus.

Hara H, Kaji A Virus Genes. 1997; 15(2):171-80.

PMID: 9421881 DOI: 10.1023/a:1007919125995.

A fps gene without gag gene sequences transforms cells in culture and induces tumors in chickens.

Foster D, Hanafusa H J Virol. 1983; 48(3):744-51.

PMID: 6605429 PMC: 255406. DOI: 10.1128/JVI.48.3.744-751.1983.

Identification of the viral sequence required for the generation of recovered avian sarcoma viruses and characterization of a series of replication-defective recovered avian sarcoma viruses.

Wang L, Beckson M, Anderson S, Hanafusa H J Virol. 1984; 49(3):881-91.

PMID: 6321772 PMC: 255550. DOI: 10.1128/JVI.49.3.881-891.1984.

DNA sequence of the viral and cellular src gene of chickens. II. Comparison of the src genes of two strains of avian sarcoma virus and of the cellular homolog.

Takeya T, Hanafusa H J Virol. 1982; 44(1):12-8.

PMID: 6292480 PMC: 256236. DOI: 10.1128/JVI.44.1.12-18.1982.

DNA sequence of the viral and cellular src gene of chickens. 1. Complete nucleotide sequence of an EcoRI fragment of recovered avian sarcoma virus which codes for gp37 and pp60src.

Takeya T, Feldman R, Hanafusa H J Virol. 1982; 44(1):1-11.

PMID: 6292477 PMC: 256235. DOI: 10.1128/JVI.44.1.1-11.1982.

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