Cloned LYT-2+ Cytolytic T Lymphocytes Destroy Allogeneic Tissue in Vivo

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1984 Jan 1

PMID 6198422

Citations 13

Authors

J D TYLER

S J Galli

M E Snider

A M Dvorak

D Steinmuller

Affiliations

Soon will be listed here.

Abstract

The long-accepted notion that alloimmune cytolytic T cells (CTL) mediate transplantation immunity has recently been called into question. In order to ascertain directly whether alloimmune CTL can mediate destruction of foreign tissue, we tested the ability of mouse CTL expanded as cloned populations in vitro to destroy allogeneic skin in vivo. The results of these studies prove unequivocally that cloned Lyt-2+ CTL can perform this task in an immunologically specific, H-2-restricted, and dose-dependent fashion.

Citing Articles

Cytotoxic activity of CD4+ T cells against autologous tumor cells.

Konomi Y, Sekine T, Takayama T, Fuji M, Tanaka T Jpn J Cancer Res. 1995; 86(9):854-60.

PMID: 7591963 PMC: 5920933. DOI: 10.1111/j.1349-7006.1995.tb03096.x.

The therapeutic significance of concomitant antitumor immunity. I. LY-1-2+ T cells from mice with a progressive tumor can cause regression of an established tumor in gamma-irradiated recipients.

NORTH R Cancer Immunol Immunother. 1984; 18(2):69-74.

PMID: 6334549 PMC: 11039104. DOI: 10.1007/BF00205736.

Different distributions of T cell subsets between perivascular and interstitial peritubular areas during rejection of rat renal allografts: a quantitative and ultrastructural study using monoclonal antibodies.

Ishikura H, Matsuura A, Ishii Y, Natori T, Kikuchi K, Aizawa M Clin Exp Immunol. 1985; 62(3):570-8.

PMID: 3910319 PMC: 1577459.

Effect of in vivo administration of Lyt antibodies. Lyt phenotype of T cells in lymphoid tissues and blocking of tumor rejection.

Nakayama E, Uenaka A J Exp Med. 1985; 161(2):345-55.

PMID: 3871834 PMC: 2187571. DOI: 10.1084/jem.161.2.345.

Specific cytotoxic T cells are found in the nonrejected kidneys of blood-transfused rats.

Dallman M, Wood K, Morris P J Exp Med. 1987; 165(2):566-71.

PMID: 3546578 PMC: 2188510. DOI: 10.1084/jem.165.2.566.

References

Miller J, Osoba D . Current concepts of the immunological function of the thymus. Physiol Rev. 1967; 47(3):437-520. DOI: 10.1152/physrev.1967.47.3.437. View

Kim B, Rosenstein M, Weiland D, Eberlein T, Rosenberg S . Clonal analysis of the lymphoid cells mediating skin allograft rejection. Mediation of graft rejection in vivo by cloned Lyt-1+2- proliferative, noncytotoxic long-term cell lines. Transplantation. 1983; 36(5):525-32. DOI: 10.1097/00007890-198311000-00011. View

Canty T, Wunderlich J . Quantitative assessment of cellular and humoral responses to skin and tumor allografts. Transplantation. 1971; 11(2):111-6. DOI: 10.1097/00007890-197102000-00001. View

Cerottini J, BRUNNER K . Cell-mediated cytotoxicity, allograft rejection, and tumor immunity. Adv Immunol. 1974; 18:67-132. DOI: 10.1016/s0065-2776(08)60308-9. View

Crowle A . Delayed hypersensitivity in the mouse. Adv Immunol. 1975; 20:197-264. DOI: 10.1016/s0065-2776(08)60209-6. View

Strom T, Tilney N, Carpenter C, BUSCH G . Identity and cytotoxic capacity of cells infiltrating renal allografts. N Engl J Med. 1975; 292(24):1257-63. DOI: 10.1056/NEJM197506122922402. View

Tilney N, Strom T, Macpherson S, Carpenter C . Surface properties and functional characteristics of infiltrating cells harvested from acutely rejecting cardiac allografts in inbred rats. Transplantation. 1975; 20(4):323-30. DOI: 10.1097/00007890-197510000-00009. View

Binz H, Wigzell H, Hayry P . Correlation between specific cytolysis and expression of idiotypic receptors of allograft-infiltrating cells. Nature. 1976; 259(5542):401-3. DOI: 10.1038/259401a0. View

Strom T, Tilney N, Paradysz J, Bancewicz J, Carpenter C . Cellular components of allograft rejection: identity, specificity, and cytotoxic function of cells infiltrating acutely rejecting allografts. J Immunol. 1977; 118(6):2020-6. View

10.

Tilney N, Strom T . Specificity of cellular migration into cardiac allografts in rats. Transplantation. 1978; 26(3):181-6. DOI: 10.1097/00007890-197809000-00011. View

11.

Willebrand E, Hayry P . Composition and in vitro cytotoxicity of cellular infiltrates in rejecting human kidney allografts. Cell Immunol. 1978; 41(2):358-72. DOI: 10.1016/0008-8749(78)90233-2. View

12.

Dvorak H, Mihm Jr M, Dvorak A, BARNES B, Manseau E, Galli S . Rejection of first-set skin allografts in man. the microvasculature is the critical target of the immune response. J Exp Med. 1979; 150(2):322-37. PMC: 2185628. DOI: 10.1084/jem.150.2.322. View

13.

Willebrand E, Soots A, Hayry P . In situ effector mechanisms in rat kidney allograft rejection. I. Characterization of the host cellular infiltrate in rejecting allograft parenchyma. Cell Immunol. 1979; 46(2):309-26. DOI: 10.1016/0008-8749(79)90419-2. View

14.

Andrus L, Prowse S, Lafferty K . Interleukin 2 production by both Ly2+ and Ly2- T-cell subsets. Scand J Immunol. 1981; 13(3):297-301. DOI: 10.1111/j.1365-3083.1981.tb00138.x. View

15.

Swain S, Dennert G, Wormsley S, Dutton R . The Lyt phenotype of a long-term allospecific T cell line. Both helper and killer activities to IA are mediated by Ly-1 cells. Eur J Immunol. 1981; 11(3):175-80. DOI: 10.1002/eji.1830110304. View

16.

Loveland B, Hogarth P, Ceredig R, McKenzie I . Cells mediating graft rejection in the mouse. I. Lyt-1 cells mediate skin graft rejection. J Exp Med. 1981; 153(5):1044-57. PMC: 2186155. DOI: 10.1084/jem.153.5.1044. View

17.

Loveland B, McKenzie I . Cells mediating graft rejection in the mouse. II. The Ly phenotypes of cells producing tumor allograft rejection. Transplantation. 1982; 33(2):174-80. DOI: 10.1097/00007890-198202000-00013. View

18.

Brooks C, Kuribayashi K, Sale G, Henney C . Characterization of five cloned murine cell lines showing high cytolytic activity against YAC-1 cells. J Immunol. 1982; 128(5):2326-35. View

19.

Loveland B, McKenzie I . Which T cells cause graft rejection?. Transplantation. 1982; 33(3):217-21. DOI: 10.1097/00007890-198203000-00001. View

20.

Loveland B, McKenzie I . Delayed-type hypersensitivity and allograft rejection in the mouse: correlation of effector cell phenotype. Immunology. 1982; 46(2):313-20. PMC: 1555378. View