The Use of a Monoclonal I-j-specific Antibody to Distinguish Cells in the Feedback Suppression Circuit from Those in the Contrasuppressor Circuit

Overview

Journal Immunogenetics

Specialties Allergy & Immunology
Genetics

Date 1982 Jan 1

PMID 6190738

Citations 4

Authors

K Yamauchi

M Taniguchi

D Green

R K GERSHON

Affiliations

Soon will be listed here.

Abstract

A monoclonal anti-I-Jb serum designated D-7 reacts in high titer with three different T-cell subsets and one cell-free product involved in generating contrasuppressive activity, but has no activity against I-J T-cell subsets (or their cell-free mediators) involved in feedback suppression. These results give evidence for heterogeneity in the I-J subregion. They also indicate that the serological markers on I-J+ cells may define the functional activity of the regulatory circuits they belong to. Clearly, they do not separate the role that the cells play within a particular immunoregulatory circuit, i.e., inducer, transducer, or effector cells.

Citing Articles

Ontogenic development of contrasuppression.

Skowron-Cendrzak A, Rybczynska Z, GERSHON R, Ptak W Proc Natl Acad Sci U S A. 1983; 80(16):5052-5.

PMID: 6576375 PMC: 384186. DOI: 10.1073/pnas.80.16.5052.

Feedback control of the secondary antibody response. II. Differences in the rate of induction of T-helper and T-suppressor memory.

Kennedy M, Thomas D Immunology. 1983; 50(2):297-302.

PMID: 6225731 PMC: 1454330.

Induction of contrasuppression is restricted by genes mapping to the IgH locus.

Green D, Chue B, Flood P Immunol Res. 1988; 7(1):82-92.

PMID: 2897413 DOI: 10.1007/BF02918156.

Function and regulation of SRBC-induced contrasuppressor T cells which modulate suppression of MOPC-315 cell secretory differentiation in vivo and in vitro.

Rohrer J, Kemp J Immunol Res. 1988; 7(1):45-55.

PMID: 2897410 DOI: 10.1007/BF02918153.

References

NIEDERHUBER J, Allen P, Mayo L . The expression of Ia antigenic determinants on macrophages required for the in vitro antibody response. J Immunol. 1979; 122(4):1342-9. View

Fresno M, Nabel G, Furthmayer H, CANTOR H . Antigen-specific T lymphocyte clones. I. Characterization of a T lymphocyte clone expressing antigen-specific suppressive activity. J Exp Med. 1981; 153(5):1246-59. PMC: 2186154. DOI: 10.1084/jem.153.5.1246. View

Tada T, Okumura K . The role of antigen-specific T cell factors in the immune response. Adv Immunol. 1979; 28:1-87. DOI: 10.1016/s0065-2776(08)60799-3. View

Yamauchi K, Murphy D, CANTOR H, GERSHON R . Analysis of antigen-specific, Ig-restricted cell-free material made by I-J+ Ly-1 cells (Ly-1 TsiF) that induces Ly-2+ cells to express suppressive activity. Eur J Immunol. 1981; 11(11):905-12. DOI: 10.1002/eji.1830111110. View

Habu S, Yamauchi K, GERSHON R, Murphy D . A non-T:non-B cell bears I-A, I-E, I-J, and Tla (Qa-1?) determinants. Immunogenetics. 1981; 13(3):215-25. DOI: 10.1007/BF00350788. View

GERSHON R, Eardley D, Durum S, Green D, Shen F, Yamauchi K . Contrasuppression. A novel immunoregulatory activity. J Exp Med. 1981; 153(6):1533-46. PMC: 2186199. DOI: 10.1084/jem.153.6.1533. View

Yamauchi K, Green D, Eardley D, Murphy D, GERSHON R . Immunoregulatory circuits that modulate responsiveness to suppressor cell signal. Failure of B10 mice to respond to suppressor factors can be overcome by quenching the contrasuppressor circuit. J Exp Med. 1981; 153(6):1547-61. PMC: 2186175. DOI: 10.1084/jem.153.6.1547. View

Murphy D, Yamauchi K, Habu S, Eardley D, GERSHON R . T cells in a suppressor circuit and non-T:non-B cells bear different I-J determinants. Immunogenetics. 1981; 13(3):205-13. DOI: 10.1007/BF00350787. View

Taniguchi M, Tada T, Tokuhisa T . Properties of the antigen-specific suppressive T-cell factor in the regulation of antibody response of the mouse. III. Dual gene control of the T-cell-mediated suppression of the antibody response. J Exp Med. 1976; 144(1):20-31. PMC: 2190361. DOI: 10.1084/jem.144.1.20. View

10.

Germain R, Benacerraf B . Helper and suppressor T cell factors. Springer Semin Immunopathol. 1980; 3(1):93-127. DOI: 10.1007/BF00199927. View

11.

Taniguchi M, Saito T, Takei I, Tokuhisa T . Presence of interchain disulfide bonds between two gene products that compose the secreted form of an antigen-specific suppressor factor. J Exp Med. 1981; 153(6):1672-7. PMC: 2186189. DOI: 10.1084/jem.153.6.1672. View

12.

Taussig M, Holliman A . Structure of an antigen-specific suppressor factor produced by a hybrid T-cell line. Nature. 1979; 277(5694):308-10. DOI: 10.1038/277308a0. View

13.

Mattingly J, Kaplan J, Janeway Jr C . Two distinct antigen-specific suppressor factors induced by the oral administration of antigen. J Exp Med. 1980; 152(3):545-54. PMC: 2185915. DOI: 10.1084/jem.152.3.545. View

14.

Ptak W, Rosenstein R, GERSHON R . Interactions between molecules (subfactors) released by different T cell sets that yield a complete factor with biological (suppressive) activity. Proc Natl Acad Sci U S A. 1982; 79(7):2375-8. PMC: 346196. DOI: 10.1073/pnas.79.7.2375. View

15.

Meruelo D, Flieger N, Smith D, McDevitt H . In vivo or in vitro treatments with anti-I-J alloantisera abolish immunity to AKR leukemia. Proc Natl Acad Sci U S A. 1980; 77(4):2178-82. PMC: 348675. DOI: 10.1073/pnas.77.4.2178. View

16.

Tada T, Takemori T, Okumura K, Nonaka M, Tokuhisa T . Two distinct types of helper T cells involved in the secondary antibody response: independent and synergistic effects of Ia- and Ia+ helper T cells. J Exp Med. 1978; 147(2):446-58. PMC: 2184496. DOI: 10.1084/jem.147.2.446. View

17.

Janeway Jr C, Sharrow S, Simpson E . T-cell populations with different functions. Nature. 1975; 253(5492):544-6. DOI: 10.1038/253544a0. View

18.

Fresno M, Nabel G, CANTOR H . Antigen-specific T lymphocyte clones. II. Purification and biological characterization of an antigen-specific suppressive protein synthesized by cloned T cells. J Exp Med. 1981; 153(5):1260-74. PMC: 2186167. DOI: 10.1084/jem.153.5.1260. View

19.

Kanno M, Kobayashi S, Tokuhisa T, Takei I, Shinohara N, Taniguchi M . Monoclonal antibodies that recognize the product controlled by a gene in the I-J subregion of the mouse H-2 complex. J Exp Med. 1981; 154(5):1290-304. PMC: 2186516. DOI: 10.1084/jem.154.5.1290. View

20.

Yamauchi K, Murphy D, CANTOR H, GERSHON R . Analysis of an antigen-specific H-2-restricted cell-free products(s) made by "I-J-" Ly-2 cells (Ly-2 TsF) that suppresses Ly-2 cell-depleted spleen cell activity. Eur J Immunol. 1981; 11(11):913-8. DOI: 10.1002/eji.1830111111. View