Dw/LD-related Molecular Polymorphism of DR4 Beta-chains

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1983 May 1

PMID 6189945

Citations 24

Authors

J P Groner

A J Watson

F H Bach

Affiliations

Soon will be listed here.

Abstract

The results of this study demonstrate the existence of molecular heterogeneity (polymorphism) within DR beta-chains isolated from a single serologically defined DR phenotype, DR4. The data are consistent with the possibility that this polymorphism is related to the Dw/LD phenotype as defined with the cellular reagents, homozygous typing cells.

Citing Articles

Specific HLA-DR4-associated histocompatibility molecules characterize patients with seropositive juvenile rheumatoid arthritis.

Nepom B, Nepom G, Mickelson E, Schaller J, Antonelli P, Hansen J J Clin Invest. 1984; 74(1):287-91.

PMID: 6610692 PMC: 425211. DOI: 10.1172/JCI111413.

Structural polymorphism of human Ia antigens recognized by the monoclonal antibody I2 and by cross-reacting I-Ek-specific alloantibodies.

Igarashi M, Obata F, Yoshii M, Kashiwagi N, Ferrone S Immunogenetics. 1984; 19(3):249-55.

PMID: 6584396 DOI: 10.1007/BF00364768.

The HLA-DR4 family of haplotypes consists of series of distinct DR and DS molecules.

Nepom G, Nepom B, Antonelli P, Mickelson E, Silver J, Goyert S J Exp Med. 1984; 159(2):394-404.

PMID: 6420500 PMC: 2187232. DOI: 10.1084/jem.159.2.394.

Electrophoretic analysis of human HLA-DR antigens from HLA-DR4 homozygous cell lines: correlation between beta-chain diversity and HLA-D.

Nepom B, Nepom G, Mickelson E, Antonelli P, Hansen J Proc Natl Acad Sci U S A. 1983; 80(22):6962-6.

PMID: 6417660 PMC: 390106. DOI: 10.1073/pnas.80.22.6962.

Close association between the Dw14 (LD40) subtype of HLA-DR4 and a restriction element for antigen-specific T-cell clones.

Qvigstad E, Thorsby E, Reinsmoen N, Bach F Immunogenetics. 1984; 20(5):583-8.

PMID: 6209217 DOI: 10.1007/BF00364360.

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