Human B-cell Alloantigens DC1, MT1, and LB12 Are Identical to Each Other but Distinct from the HLA-DR Antigen

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1981 Jul 1

PMID 6974868

Citations 66

Authors

D A Shackelford

D L Mann

J J van Rood

G B Ferrara

J L Strominger

Affiliations

Soon will be listed here.

Abstract

Some human B-lymphoblastoid cell lines are shown to express at least two types of Ia-like antigens. One antigen is defined by alloantisera to HLA-DR, and the other antigen is defined by alloantisera and a monoclonal antibody to the specificities DC1, MT1 (MB1), and LB12, which are in linkage disequilibrium with HLA-DR. The subunits of the DC1 molecule differ from those of the DR molecule. The light chains of both molecules are structurally polymorphic.

Citing Articles

Complete nucleotide sequence characterization of DRB5 alleles reveals a homogeneous allele group that is distinct from other DRB genes.

Barsakis K, Babrzadeh F, Chi A, Mallempati K, Pickle W, Mindrinos M Hum Immunol. 2019; 80(7):437-448.

PMID: 30954494 PMC: 6622178. DOI: 10.1016/j.humimm.2019.04.001.

Multiple mismatches at the low expression HLA loci DP, DQ, and DRB3/4/5 associate with adverse outcomes in hematopoietic stem cell transplantation.

Fernandez-Vina M, Klein J, Haagenson M, Spellman S, Anasetti C, Noreen H Blood. 2013; 121(22):4603-10.

PMID: 23596045 PMC: 3668493. DOI: 10.1182/blood-2013-02-481945.

Complete sequence of an HLA-dR beta chain deduced from a cDNA clone and identification of multiple non-allelic DR beta chain genes.

Long E, Wake C, Gorski J, MACH B EMBO J. 1983; 2(3):389-94.

PMID: 11894954 PMC: 555145. DOI: 10.1002/j.1460-2075.1983.tb01435.x.

Polymorphism and complexity of the human DC and murine I-A alpha chain genes.

Auffray C, Ben-Nun A, Germain R, Seidman J, Strominger J EMBO J. 1983; 2(1):121-4.

PMID: 11894898 PMC: 555098. DOI: 10.1002/j.1460-2075.1983.tb01392.x.

Human MHC class II molecules as differentiation markers.

Van Heyningen V, Guy K, Newman R, Steel C Immunogenetics. 1982; 16(5):459-69.

PMID: 6984012 DOI: 10.1007/BF00372104.

References

Ferrara G . Identification of new cell surface markers in man: the problem of immunogenicity. Transplant Proc. 1979; 11(1):715-8. View

Reinertsen J, Klippel J, Johnson A, Steinberg A, Decker J, Mann D . B-lymphocyte alloantigens associated with systemic lupus erythematosus. N Engl J Med. 1978; 299(10):515-8. DOI: 10.1056/NEJM197809072991004. View

Lampson L, Levy R . Two populations of Ia-like molecules on a human B cell line. J Immunol. 1980; 125(1):293-9. View

Laemmli U . Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970; 227(5259):680-5. DOI: 10.1038/227680a0. View

Charron D, McDevitt H . Characterization of HLA-D-region antigens by two-dimensional gel electrophoresis. Molecular-genotyping. J Exp Med. 1980; 152(2 Pt 2):18s-36s. View

Silver J, Ferrone S . Structural polymorphism of human DR antigens. Nature. 1979; 279(5712):436-7. DOI: 10.1038/279436a0. View

Markert M, Cresswell P . Polymorphism of human B-cell alloantigens: evidence for three loci within the HLA system. Proc Natl Acad Sci U S A. 1980; 77(10):6101-4. PMC: 350221. DOI: 10.1073/pnas.77.10.6101. View

Moutsopoulos H, Mann D, Johnson A, Chused T . Genetic differences between primary and secondary sicca syndrome. N Engl J Med. 1979; 301(14):761-3. DOI: 10.1056/NEJM197910043011405. View

McMillan M, Cecka J, Hood L, Murphy D, McDevitt H . Peptide map analyses of murine Ia antigens of the I-E subregion using HPLC. Nature. 1979; 277(5698):663-5. DOI: 10.1038/277663a0. View

10.

Kessler S . Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interaction of antibody-antigen complexes with protein A. J Immunol. 1975; 115(6):1617-24. View

11.

Kaufman J, Strominger J . Both chains of HLA-DR bind to the membrane with a penultimate hydrophobic region and the heavy chain is phosphorylated at its hydrophilic carboxyl terminus. Proc Natl Acad Sci U S A. 1979; 76(12):6304-8. PMC: 411852. DOI: 10.1073/pnas.76.12.6304. View

12.

Duquesnoy R, Marrari M, Annen K . Identification of an HLA-DR-associated system of B-cell alloantigens. Transplant Proc. 1979; 11(4):1757-60. View

13.

UHR J, Capra J, Vitetta E, Cook R . Organization of the immune response genes. Science. 1979; 206(4416):292-7. DOI: 10.1126/science.113876. View

14.

Moutsopoulos H, Chused T, Johnson A, Khudsen B, Mann D . B lymphocyte antigens in sicca syndrome. Science. 1978; 199(4336):1441-2. DOI: 10.1126/science.415366. View

15.

Shackelford D, Strominger J . Demonstration of structural polymorphism among HLA-DR light chains by two-dimensional gel electrophoresis. J Exp Med. 1980; 151(1):144-65. PMC: 2185749. DOI: 10.1084/jem.151.1.144. View

16.

Cook R, Vitetta E, UHR J, Capra J . Structural studies on the murine Ia alloantigens--III. Tryptic peptide comparisons of allelic products of the I-E/C sub-region. Mol Immunol. 1979; 16(1):29-35. DOI: 10.1016/0161-5890(79)90024-5. View

17.

Silver J, Walker L, Reisfeld R, Pellegrino M, Ferrone S . Structural studies of murine I-E and human DR antigens. Mol Immunol. 1979; 16(1):37-42. DOI: 10.1016/0161-5890(79)90025-7. View

18.

Broder S, Mann D, Waldmann T . Participation of suppressor T cells in the immunosuppressive activity of a heteroantiserum to human Ia-like antigens (p23,30). J Exp Med. 1980; 151(1):257-62. PMC: 2185755. DOI: 10.1084/jem.151.1.257. View

19.

Tosi R, TANIGAKI N, Centis D, Ferrara G, Pressman D . Immunological dissection of human Ia molecules. J Exp Med. 1978; 148(6):1592-611. PMC: 2185093. DOI: 10.1084/jem.148.6.1592. View

20.

Kaufman J, Andersen R, Strominger J . HLA-DR antigens have polymorphic light chains and invariant heavy chains as assessed by lysine-containing tryptic peptide analysis. J Exp Med. 1980; 152(2 Pt 2):37s-53s. View