Multiple Human Beta Interferon Genes

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1982 Sep 1

PMID 6180119

Citations 11

Authors

A D Sagar

P B Sehgal

D L Slate

F H Ruddle

Affiliations

Soon will be listed here.

Abstract

Analysis of human beta interferon (IFN) mRNA preparations obtained from poly(I) . poly (C)-induced human diploid fibroblasts (FS-4) and from several similarly induced human-mouse somatic cell hybrids by electrophoresis through agarose-CH3HgOH tube gels led to the detection of at least five translationally active human IFN-beta mRNA species. The results obtained are consistent with the existence of IFN-beta genes on different human chromosomes. Marked cell-dependent variability in the expression of these IFN mRNA species was observed.

Citing Articles

The chromosomal location of mouse interferon alpha genes.

Lovett M, Cox D, Yee D, Boll W, Weissmann C, Epstein C EMBO J. 1984; 3(7):1643-6.

PMID: 6745245 PMC: 557571. DOI: 10.1002/j.1460-2075.1984.tb02023.x.

Structure and expression in Escherichia coli of a cloned rat interferon-alpha gene.

Dijkema R, Pouwels P, de Reus A, Schellekens H Nucleic Acids Res. 1984; 12(2):1227-42.

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Isolation of novel human genomic DNA clones related to human interferon-beta 1 cDNA.

Sehgal P, May L, Sagar A, LaForge K, Inouye M Proc Natl Acad Sci U S A. 1983; 80(12):3632-6.

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The interferons.

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Structure and expression of cloned murine IFN-alpha genes.

Shaw G, Boll W, Taira H, Mantei N, Lengyel P, Weissmann C Nucleic Acids Res. 1983; 11(3):555-73.

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