Antigen-specific Production of Immune Interferon by T Cells Lines

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1982 Apr 1

PMID 6174674

Citations 7

Authors

J L McKimm-Breschkin

P L Mottram

W R Thomas

J F Miller

Affiliations

Soon will be listed here.

Abstract

Continuous cultures of T cells reactive to the hapten 4-ethoxymethylene-2-phenyloxazolone were tested for interferon production after antigenic stimulation in vitro. Induction of interferon was antigen-specific and also restricted by the I region of the major histocompatibility complex. Kinetics of antigen induced interferon production were different from those reported for mitogen induced synthesis.

Citing Articles

Human immunodeficiency virus type 1-specific cytotoxic T lymphocytes release gamma interferon, tumor necrosis factor alpha (TNF-alpha), and TNF-beta when they encounter their target antigens.

Jassoy C, Harrer T, Rosenthal T, Navia B, Worth J, Johnson R J Virol. 1993; 67(5):2844-52.

PMID: 7682629 PMC: 237609. DOI: 10.1128/JVI.67.5.2844-2852.1993.

Anti-T-cell idiotype activity in serum of mice injected with syngeneic hapten-specific T-cell lines.

Thomas W, Mottram P, Miller J Proc Natl Acad Sci U S A. 1982; 79(21):6671-4.

PMID: 6983074 PMC: 347190. DOI: 10.1073/pnas.79.21.6671.

Specific adoptive immunotherapy of malignant glioma with long-term cytotoxic T lymphocyte line expanded in T-cell growth factor. Experimental study and future prospects.

Yamasaki T, Handa H, Yamashita J, Watanabe Y, Namba Y, Hanaoka M Neurosurg Rev. 1984; 7(1):37-54.

PMID: 6611523 DOI: 10.1007/BF01743289.

Monoclonal antibodies against murine gamma interferon.

Prat M, Gribaudo G, Comoglio P, Cavallo G, Landolfo S Proc Natl Acad Sci U S A. 1984; 81(14):4515-9.

PMID: 6431408 PMC: 345621. DOI: 10.1073/pnas.81.14.4515.

Immune human lymphocytes produce an acid-labile alpha-interferon.

Balkwill F, Griffin D, Band H, Beverley P J Exp Med. 1983; 157(3):1059-63.

PMID: 6403647 PMC: 2186960. DOI: 10.1084/jem.157.3.1059.

References

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