P L Mottram
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Explore the profile of P L Mottram including associated specialties, affiliations and a list of published articles.
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60
Citations
191
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Recent Articles
1.
Crimeen-Irwin B, Scalzo K, Gloster S, Mottram P, Plebanski M
Curr Drug Targets Immune Endocr Metabol Disord
. 2005 Dec;
5(4):413-22.
PMID: 16375694
The immune system is a tightly regulated network that is able to maintain a balance of immune homeostasis under normal physiological conditions. Normally, when challenged with foreign antigen, specific appropriate...
2.
Lehnert A, Mottram P, Han W, Walters S, Patel A, Hawthorne W, et al.
Transpl Immunol
. 2001 Oct;
9(1):51-6.
PMID: 11680572
Previously, we demonstrated that combination CTLA4-Fc and anti-CD40L mAb treatment results in tolerance to concordant, cellular islet xenografts. The aim of this study was to determine its effectiveness in a...
3.
Mottram P, Murray-Segal L, Han W, Zhan Y, Brady J, Lew A
Transpl Immunol
. 2001 Jan;
8(3):203-9.
PMID: 11147701
To compare the effectiveness of transgenic and systemic monoclonal antibody therapy for pancreas transplantation, vascularised segmental pancreas allografts from wild-type or transgenic pancreatic tissue that secreted monoclonal anti-CD4 were placed...
4.
Han W, Zhan Y, Murray-Segal L, Brady J, Lew A, Mottram P
Transplantation
. 2000 Aug;
70(1):168-74.
PMID: 10919596
Background: Investigations of the role of CD4 T lymphocytes in allograft rejection and tolerance have relied on the use of mouse models with a deficiency in CD4 cells. However, in...
5.
Han W, Murray-Segal L, Gershenzon A, Zhang J, Hodder A, Pietersz G, et al.
Transpl Immunol
. 2000 Jan;
7(4):207-13.
PMID: 10638833
In order to reduce the toxic effects of the T cell activating anti-CD3 monoclonal antibody, 145-2C11, F(ab')2 fragments were prepared by pepsin digestion. These fragments were then used as non-immunosuppressive...
6.
Han W, Murray-Segal L, Mottram P
Microsurgery
. 1999 Sep;
19(6):272-4.
PMID: 10469441
This study describes a new method for joining the donor ureter to the recipient bladder during mouse kidney transplantation. The donor left kidney was harvested using methods previously published, except...
7.
Han W, Murray-Segal L, Mottram P
Transpl Immunol
. 1999 Jun;
7(1):37-44.
PMID: 10375076
The study was designed to compare second heart and skin grafts and in vitro assays as a means of assessing peripheral tolerance in C57BL/6 mice. Vascularized heterotopic BALB/c hearts were...
8.
Mottram P, Han W, Murray-Segal L, Pietersz G, McKenzie I
Transplant Proc
. 1999 Mar;
31(1-2):1414-5.
PMID: 10083624
No abstract available.
9.
Mottram P, Raisanen-Sokolowski A, Russell M
Transplantation
. 1998 Dec;
66(11):1510-8.
PMID: 9869093
Background: To evaluate cardiac allografts from recipients that had achieved peripheral tolerance after transient CD4+ T cell depletion, we analyzed cellular infiltrate, cytokine expression, and vascular thickening. Long-surviving cardiac allografts...
10.
Mottram P, Murray-Segal L, Han W, Maguire J, Mandel T
Diabetes
. 1998 Sep;
47(9):1399-405.
PMID: 9726227
Spontaneously diabetic nonobese diabetic (NOD/Lt) mice were treated with anti-T-cell monoclonal antibodies (mAbs) at the time of grafting with vascularized segmental pancreas isografts. Recipients were either untreated or given anti-CD4...