Comparison of Histologic and Immunologic Heterogeneity of Non-Hodgkin's Lymphomas

Overview

Journal Am J Pathol

Publisher Elsevier

Specialty Pathology

Date 1981 Nov 1

PMID 6170233

Citations 7

Authors

M J Borowitz

B P Croker

R S METZGAR

Affiliations

Soon will be listed here.

Abstract

The lymphocyte surface marker phenotype in 11 selected cases of non-Hodgkin's lymphomas was determined with anti-immunoglobulin and mouse monoclonal antibodies against human lymphocyte antigens. A complement-mediated cell cytotoxicity assay on suspensions of the tumor cells was compared with an indirect immunoperoxidase technique on frozen tissue sections. Both methods gave good results in tumors with a uniform cell population, but the frozen section technique was superior in heterogeneous tumors. The six B-cell neoplasms were heterogeneous with respect to expression of surface immunoglobulin and Ia antigens. The five T-cell tumors were morphologically heterogeneous and also highly variable in their expression of different T-cell specific antigens.

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