Correlated Ultrastructural and Immunological Findings in CD8+ and CD4+ Peripheral T-cell Lymphomas

Overview

Journal Med Oncol Tumor Pharmacother

Specialties Oncology
Pharmacology

Date 1988 Jan 1

PMID 3261823

Authors

F Osculati

S Cinti

M Reynes

G Balercia

C Canon

V Tricottet

D Dantchev

G MATHE

Affiliations

Soon will be listed here.

Abstract

Ultrastructural features of CD8+ and CD4+ peripheral T-cell lymphomas were studied and the results revealed distinct traits correlated with phenotype. CD8+ peripheral T-cell lymphomas were characterized by a rich organular pattern with a well-developed Golgi apparatus, dense granules, numerous and atypical giant mitochondria. CD4+ peripheral T-cell lymphomas were characterized by wide cytoplasmic areas devoid of organelles. Since similar ultrastructural features differentiated normal and pathological CD8+ and CD4+ peripheral T-lymphocytes, we conclude that under both normal and pathological conditions the expression on the part of the peripheral T-lymphocytes of CD8+ and CD4+ phenotypes is associated to morphological features which distinguish the two subsets.

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