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Cross-bridge Properties Derived from Muscle Isotonic Velocity Transients

Overview
Journal Proc Natl Acad Sci U S A
Specialty Science
Date 1969 Oct 1
PMID 5261029
Citations 39
Authors
R J PODOLSKY
A C NOLAN
S A Zaveler
Affiliations
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Abstract

The rate constants for the turnover of cross-bridges during frog muscle contraction were determined from an analysis of the motion that follows step decreases in load. For a given projection from the myosin filament, there appears to be a range of about 100 A along the length of the filament over which the projection can attach to the actin filament and form a cross-bridge. The site of attachment is then displaced by a distance of this same order before the link is broken. The values of the rate constants also imply that a cross-bridge is formed each time an actin site comes within range of a myosin projection, so that the turnover of cross-bridges for a given contraction distance is independent of the speed of the motion.

Citing Articles

On the Shape of the Force-Velocity Relationship in Skeletal Muscles: The Linear, the Hyperbolic, and the Double-Hyperbolic.

Alcazar J, Csapo R, Ara I, Alegre L Front Physiol. 2019; 10:769.

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Mathematical simulation of muscle cross-bridge cycle and force-velocity relationship.

Chin L, Yue P, Feng J, Seow C Biophys J. 2006; 91(10):3653-63.

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A program for developing a comprehensive mathematical description of the crossbridge cycle of muscle.

Slawnych M, Seow C, HUXLEY A, Ford L Biophys J. 1994; 67(4):1669-77.

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Structural changes in myosin cross-bridges during shortening of frog skeletal muscle.

Yagi N, Takemori S J Muscle Res Cell Motil. 1995; 16(1):57-63.

PMID: 7751405 DOI: 10.1007/BF00125310.

Isotonic velocity transients in frog muscle fibres following quick changes in load.

Sugi H, Tsuchiya T J Physiol. 1981; 319:219-38.

PMID: 7320912 PMC: 1243833. DOI: 10.1113/jphysiol.1981.sp013903.

References
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