Alpha 2.0
Login Register
» Articles » PMID: 5123890

A Requirement for Dietary Lipids for Induction of Cytochrome P-450 by Phenobarbitone in Rat Liver Microsomal Fraction

Overview
Journal Biochem J
Specialty Biochemistry
Date 1971 May 1
PMID 5123890
Citations 22
Authors
W J Marshall
A E McLean
Affiliations
Soon will be listed here.
Abstract

1. Rats fed on purified synthetic diets have a markedly lower cytochrome P-450 concentration and hydroxylating enzyme activity in liver microsomal fraction than rats fed on stock pellets. 2. When both groups are treated with phenobarbitone the difference is even greater, the purified diet allowing only 50% of the cytochrome P-450 concentrations of controls. 3. Addition of herring oil, linoleic acid or 0.1% oxidized sitosterol to the diets allows induction of cytochrome P-450 to take place. 4. Addition of coconut oil to the diet does not permit induction of cytochrome P-450. 5. The interactions between dietary protein and the lipid substances are explored. 6. The mechanism of induction of microsomal hydroxylation enzymes by drugs is discussed in the light of these requirements.

Citing Articles

Effect of inhibitors and phenobarbital pretreatment upon hepatic lipid peroxidation during protein and riboflavin dietary stress in male rats.

Patel J, Galdhar N, Javalgekar S, Pawar S Lipids. 2016; 10(4):220-6.

PMID: 27521069 DOI: 10.1007/BF02532484.

Interaction of selenium deficiency and fat intake in the regulation of enzymes associated with peroxide metabolism.

Ip C Biol Trace Elem Res. 2013; 5(2):139-46.

PMID: 24263455 DOI: 10.1007/BF02916633.

Enzyme replacement therapy for pancreatic insufficiency: present and future.

Fieker A, Philpott J, Armand M Clin Exp Gastroenterol. 2011; 4:55-73.

PMID: 21753892 PMC: 3132852. DOI: 10.2147/CEG.S17634.

Rodent models of alcoholic liver disease.

Goldin R Int J Exp Pathol. 1994; 75(1):1-7.

PMID: 8142270 PMC: 2001789.

Effect of fat and microflora on hepatic, small intestinal and colonic HMG CoA reductase, cytochrome P450 and cytochrome B5.

Hanson D, Reddy B Lipids. 1981; 16(3):183-8.

PMID: 7219088 DOI: 10.1007/BF02535436.

References
1.
Nebert D, Gelboin H . The role of ribonucleic acid and protein synthesis in microsomal aryl hydrocarbon hydroxylase induction in cell culture. The independence of transcription and translation. J Biol Chem. 1970; 245(1):160-8. View
2.
BRETSCHER M . How repressor molecules function. Nature. 1968; 217(5128):509-11. DOI: 10.1038/217509a0. View
3.
Omura T, Sato R . THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE. J Biol Chem. 1964; 239:2370-8. View
4.
Brown R, Miller J, Miller E . The metabolism of methylated aminoazo dyes. IV. Dietary factors enhancing demethylation in vitro. J Biol Chem. 1954; 209(1):211-22. View
5.
Marshall W, McLean A . The effect of oral phenobarbitone on hepatic microsomal cytochrome P-450 and demethylation activity in rats fed normal and low protein diets. Biochem Pharmacol. 1969; 18(1):153-7. DOI: 10.1016/0006-2952(69)90020-3. View