Thrombocytopenia in Malaria with Immunoglobulin (IgM) Changes

Overview

Journal Br Med J

Specialty General Medicine

Date 1972 Feb 5

PMID 5008661

Citations 27

Authors

P J Beale

J D Cormack

T B Oldrey

Affiliations

Soon will be listed here.

Abstract

Of 33 cases of naturally occurring human malaria 32 were found to have significant thrombocytopenia. Only one patient showed signs of bleeding. The lowest platelet levels were found between the day of diagnosis and the fourth day of treatment. Thereafter they returned to normal values. No other factors could be found to correlate with the presence or depth of thrombocytopenia, and no evidence of intravascular coagulation was found in any case. A rise in the immunoglobulin IgM was found in all 13 cases in which it was estimated. Since thrombocytopenia can occur independently of intravascular coagulation the latter should be diagnosed and heparin given only after clotting factors have been shown to be depleted.

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References

Turner M, Voller A . Studies on immunoglobulins of Nigerians. I. The immunoglobulin levels of a Nigerian population. J Trop Med Hyg. 1966; 69(5):99-103. View

TOBIE J, Wolff S, Jeffery G . Immune response of man to inoculation with Plasmodium cynomolgi and challenge with P. vivax. Lancet. 1966; 2(7458):300-2. DOI: 10.1016/s0140-6736(66)92592-x. View

DENNIS L, EICHELBERGER Jr J, CONRAD M, Von Doenhoff Jr A . A coagulation defect and its treatment with heparin in Plasmodium knowlesi malaria in rhesus monkeys. Mil Med. 1966; 131(9):Suppl:1107-10. View

DEVAKUL K, Harinasuta T, REID H . 125-I-labelled fibrinogen in cerebral malaria. Lancet. 1966; 2(7469):886-8. DOI: 10.1016/s0140-6736(66)91982-9. View

DENNIS L, Eichelberger J, Inman M, CONRAD M . Depletion of coagulation factors in drug-resistant Plasmodium falciparum malaria. Blood. 1967; 29(5):713-21. View

DENNIS L, CONRAD M . Anticoagulant and antimalarial action of heparin in simian malaria. Lancet. 1968; 1(7546):769-71. DOI: 10.1016/s0140-6736(68)92225-3. View

CONRAD M . Pathophysiology of malaria. Hematologic observations in human and animal studies. Ann Intern Med. 1969; 70(1):134-41. DOI: 10.7326/0003-4819-70-1-134. View

Zuckerman A . Current status of the immunology of malaria and of the antigenic analysis of plasmodia. A five-year review. Bull World Health Organ. 1969; 40(1):55-6. PMC: 2554459. View

NEVA F, Sheagren J, Shulman N, Canfield C . Malaria: host-defense mechanisms and complications. Ann Intern Med. 1970; 73(2):295-306. DOI: 10.7326/0003-4819-73-2-295. View

10.

Beale P, Coni N . Cerebral malaria. Ann Trop Med Parasitol. 1970; 64(2):243-7. DOI: 10.1080/00034983.1970.11686687. View

11.

MCKELVEY T, Lundie A, VANREENEN R, Williams E, Moore H, Thomas M . Chloroquine-resistant falciparum malaria among British service personnel in West Malaysia and Singapore. Trans R Soc Trop Med Hyg. 1971; 65(3):286-309. DOI: 10.1016/0035-9203(71)90003-4. View

12.

Oski F, NAIMAN J, DIAMOND L . Use of the plasma acid phosphatase value in the differentiation of thrombocytopenic states. N Engl J Med. 1963; 268:1423-31. DOI: 10.1056/NEJM196306272682601. View

13.

HILL 2nd G, Knight V, Jeffery G . THROMBOCYTOPENIA IN VIVAX MALARIA. Lancet. 1964; 1(7327):240-1. DOI: 10.1016/s0140-6736(64)92347-5. View

14.

CURTAIN C, Kidson C, CHAMPNESS D, Gorman J . MALARIA ANTIBODY CONTENT OF GAMMA 2-7S GLOBULIN IN TROPICAL POPULATIONS. Nature. 1964; 203:1366-7. DOI: 10.1038/2031366a0. View

15.

ABELE D, TOBIE J, Hill G, Contacos P, Evans C . ALTERATIONS IN SERUM PROTEINS AND 19S ANTIBODY PRODUCTION DURING THE COURSE OF INDUCED MALARIAL INFECTIONS IN MAN. Am J Trop Med Hyg. 1965; 14:191-7. DOI: 10.4269/ajtmh.1965.14.191. View