The Role of Platelets in the Pathogenesis of Cerebral Malaria

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2010 Jan 22

PMID 20091081

Citations 45

Authors

Dermot Cox

Sam McConkey

Affiliations

Soon will be listed here.

Abstract

Malaria is a major cause of morbidity and mortality in the developing world and cerebral malaria is responsible for the majority of malaria-associated deaths. There is a strong association between thrombocytopenia and outcome in malaria, suggesting a role for platelets in the pathogenesis of malaria. This thrombocytopenia is likely due to platelet activation possibly through an interaction between PfEMP1 on plasmodium and CD36 on platelets. Platelet activation by plasmodium has two potential consequences. It can lead to the formation of micro-aggregates of infected red blood cells and platelets which can occlude blood vessels and it also leads to binding to and activation of the endothelium.

Citing Articles

Platelet Ido1 expression is induced during Plasmodium yoelii infection, altering plasma tryptophan metabolites.

Blick-Nitko S, Ture S, Schafer X, Munger J, Livada A, Li C Blood Adv. 2024; 8(22):5814-5825.

PMID: 39133890 PMC: 11609358. DOI: 10.1182/bloodadvances.2024013175.

An overview of qualitative and quantitative platelet abnormalities in schistosomiasis.

Abdelfattah A, Hijjawi N, Jacoub K Parasitol Res. 2024; 123(5):225.

PMID: 38809265 DOI: 10.1007/s00436-024-08245-7.

Mosquito Salivary Antigens and Their Relationship to Dengue and Malaria.

Howell M, Olajiga O, Cardenas J, Parada-Higuera C, Gonzales-Pabon M, Gutierrez-Silva L Pathogens. 2024; 13(1).

PMID: 38251359 PMC: 10818852. DOI: 10.3390/pathogens13010052.

Hematological Abnormalities Among Malaria Infected Adult Patients in Association with ABO Blood Groups at Jinella Health Center, Harar, Eastern Ethiopia.

Asmerom H, Gemechu K, Sileshi B, Arkew M J Blood Med. 2023; 14:463-476.

PMID: 37638257 PMC: 10457518. DOI: 10.2147/JBM.S419815.

Pathogenesis of Anemia in Canine Babesiosis: Possible Contribution of Pro-Inflammatory Cytokines and Chemokines-A Review.

Zygner W, Gojska-Zygner O, Norbury L Pathogens. 2023; 12(2).

PMID: 36839438 PMC: 9962459. DOI: 10.3390/pathogens12020166.

References

Pang Z, Antonetti D, Tarbell J . Shear stress regulates HUVEC hydraulic conductivity by occludin phosphorylation. Ann Biomed Eng. 2005; 33(11):1536-45. DOI: 10.1007/s10439-005-7786-0. View

Rauova L, Zhai L, Kowalska M, Arepally G, Cines D, Poncz M . Role of platelet surface PF4 antigenic complexes in heparin-induced thrombocytopenia pathogenesis: diagnostic and therapeutic implications. Blood. 2005; 107(6):2346-53. PMC: 1895727. DOI: 10.1182/blood-2005-08-3122. View

Facer C, Theodoridou A . Elevated plasma levels of P-selectin (GMP-140/CD62P) in patients with Plasmodium falciparum malaria. Microbiol Immunol. 1994; 38(9):727-31. DOI: 10.1111/j.1348-0421.1994.tb01848.x. View

Hollestelle M, Donkor C, Mantey E, Chakravorty S, Craig A, Akoto A . von Willebrand factor propeptide in malaria: evidence of acute endothelial cell activation. Br J Haematol. 2006; 133(5):562-9. DOI: 10.1111/j.1365-2141.2006.06067.x. View

LEECH J, Barnwell J, Aikawa M, MILLER L, Howard R . Plasmodium falciparum malaria: association of knobs on the surface of infected erythrocytes with a histidine-rich protein and the erythrocyte skeleton. J Cell Biol. 1984; 98(4):1256-64. PMC: 2113211. DOI: 10.1083/jcb.98.4.1256. View

Polack B, Delolme F, Peyron F . Protective role of platelets in chronic (Balb/C) and acute (CBA/J) Plasmodium berghei murine malaria. Haemostasis. 1998; 27(6):278-85. DOI: 10.1159/000217468. View

Baruch D, Pasloske B, Singh H, Bi X, Ma X, Feldman M . Cloning the P. falciparum gene encoding PfEMP1, a malarial variant antigen and adherence receptor on the surface of parasitized human erythrocytes. Cell. 1995; 82(1):77-87. DOI: 10.1016/0092-8674(95)90054-3. View

DEMAIO L, Chang Y, Gardner T, Tarbell J, Antonetti D . Shear stress regulates occludin content and phosphorylation. Am J Physiol Heart Circ Physiol. 2001; 281(1):H105-13. DOI: 10.1152/ajpheart.2001.281.1.H105. View

Yosaatmadja F, Andrews K, Duffy M, Brown G, Beeson J, Rogerson S . Characterization of VAR2CSA-deficient Plasmodium falciparum-infected erythrocytes selected for adhesion to the BeWo placental cell line. Malar J. 2008; 7:51. PMC: 2329659. DOI: 10.1186/1475-2875-7-51. View

10.

Herczenik E, Bouma B, Korporaal S, Strangi R, Zeng Q, Gros P . Activation of human platelets by misfolded proteins. Arterioscler Thromb Vasc Biol. 2007; 27(7):1657-65. DOI: 10.1161/ATVBAHA.107.143479. View

11.

Hall N, Pain A, Berriman M, Churcher C, Harris B, Harris D . Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Nature. 2002; 419(6906):527-31. DOI: 10.1038/nature01095. View

12.

Silverstein R, Asch A, Nachman R . Glycoprotein IV mediates thrombospondin-dependent platelet-monocyte and platelet-U937 cell adhesion. J Clin Invest. 1989; 84(2):546-52. PMC: 548914. DOI: 10.1172/JCI114197. View

13.

Watier H, Verwaerde C, Landau I, Werner E, Fontaine J, Capron A . T-cell-dependent immunity and thrombocytopenia in rats infected with Plasmodium chabaudi. Infect Immun. 1992; 60(1):136-42. PMC: 257513. DOI: 10.1128/iai.60.1.136-142.1992. View

14.

Chotivanich K, Sritabal J, Udomsangpetch R, Newton P, Stepniewska K, Ruangveerayuth R . Platelet-induced autoagglutination of Plasmodium falciparum-infected red blood cells and disease severity in Thailand. J Infect Dis. 2004; 189(6):1052-5. DOI: 10.1086/381900. View

15.

Grau G, Piguet P, Gretener D, Vesin C, Lambert P . Immunopathology of thrombocytopenia in experimental malaria. Immunology. 1988; 65(4):501-6. PMC: 1385556. View

16.

Howard R, Barnwell J, Rock E, Neequaye J, Ofori-Adjei D, Maloy W . Two approximately 300 kilodalton Plasmodium falciparum proteins at the surface membrane of infected erythrocytes. Mol Biochem Parasitol. 1988; 27(2-3):207-23. DOI: 10.1016/0166-6851(88)90040-0. View

17.

Karanikas G, Zedwitz-Liebenstein K, Eidherr H, Schuetz M, Sauerman R, Dudczak R . Platelet kinetics and scintigraphic imaging in thrombocytopenic malaria patients. Thromb Haemost. 2004; 91(3):553-7. DOI: 10.1160/TH03-07-0489. View

18.

Adam C, Geniteau M, Verroust P, Lebras J, Gibert C, MOREL-MAROGER L . Cryoglobulins, circulating immune complexes, and complement activation in cerebral malaria. Infect Immun. 1981; 31(2):530-5. PMC: 351340. DOI: 10.1128/iai.31.2.530-535.1981. View

19.

Wassmer S, Combes V, Candal F, Juhan-Vague I, Grau G . Platelets potentiate brain endothelial alterations induced by Plasmodium falciparum. Infect Immun. 2005; 74(1):645-53. PMC: 1346683. DOI: 10.1128/IAI.74.1.645-653.2006. View

20.

Langer H, Gawaz M . [The role of platelets for the pathophysiology of acute coronary syndromes]. Hamostaseologie. 2006; 26(2):114-8. View