Effect of Central Catecholamine Depletion on the Osmotic and Nonosmotic Stimulation of Vasopressin (antidiuretic Hormone) in the Rat

Overview

Journal J Clin Invest

Specialty General Medicine

Date 1979 Dec 1

PMID 500827

Citations 14

Authors

T R Miller

W A Handelman

P E Arnold

K M McDonald

P B Molinoff

R W Schrier

Affiliations

Soon will be listed here.

Abstract

The central nervous system (CNS) mechanism(s) for the release of antidiuretic hormone (ADH) by various stimuli is unknown. In this study, the role of CNS catecholamines in effecting ADH release was examined in conscious rats 10-14 d after the cerebroventricular injection of 6-hydroxydopamine (6-OHDA). This dose of 6-OHDA caused a 67% depletion of brain tissue norepinephrine and only 3% depletion of heart norepinephrine, as compared with controls, which were injected with the vehicle buffer alone. Either intravenous 3% saline (osmotic stimulus) or intraperitoneal hyperoncotic dextran (nonosmotic stimulus) was administered to water-diuresing rats through indwelling catheters. Neither of these maneuvers changed arterial pressure, pulse, or inulin clearance in control or 6-OHDA rats. The 3% saline caused similar increases in plasma osmolality (15 mosmol/kg H(2)O) in control and 6-OHDA rats. The control rats, however, increased urinary osmolality (Uosm) to 586 mosmol/kg H(2)O, whereas 6-OHDA rats increased Uosm only to 335 mosmol/kg H(2)O (P < 0.005). These changes in Uosm were accompanied by an increase in plasma ADH to 7.6 muIU/ml in control animals vs. 2.9 muIU/ml in 6-OHDA rats (P < 0.005). All waterdiuresing animals had undetectable plasma ADH levels. Dextran-induced hypovolemia caused similar decrements (- 10%) in blood volume in both control and 6-OHDA animals, neither of which had significant changes in plasma osmolality. This nonosmotic hypovolemic stimulus caused an increase in Uosm to 753 mosmol/kg H(2)O in control rats, whereas Uosm in 6-OHDA rats increased to only 358 mosmol/kg H(2)O (P < 0.001). At the same time, ADH levels also were significantly greater in Cont rats (2.4 muIU/ml) than in the 6-OHDA animals (0.69 muIU/ml; P < 0.05). These results therefore suggest that CNS catecholamines may play an important role in mediating ADH release in response to both osmotic and nonosmotic (hypovolemic) stimuli.

Citing Articles

Copeptin as a marker of relative arginine vasopressin deficiency after pediatric cardiac surgery.

Mastropietro C, Mahan M, Valentine K, Clark J, Hines P, Walters 3rd H Intensive Care Med. 2012; 38(12):2047-54.

PMID: 23093248 DOI: 10.1007/s00134-012-2731-9.

Homologous upregulation of human arterial alpha-adrenergic responses by guanadrel.

Hogikyan R, Supiano M J Clin Invest. 1993; 91(4):1429-35.

PMID: 8473492 PMC: 288117. DOI: 10.1172/JCI116347.

Effect of endothelin-3 on vasopressin release in vitro and water excretion in vivo in Long-Evans rats.

Rossi N J Physiol. 1993; 461:501-11.

PMID: 8350273 PMC: 1175269. DOI: 10.1113/jphysiol.1993.sp019525.

The physiology of vasopressin release and the pathogenesis of impaired water excretion in adrenal, thyroid, and edematous disorders.

Schrier R, Goldberg J Yale J Biol Med. 1980; 53(6):525-41.

PMID: 7245804 PMC: 2595929.

Evidence for the involvement of a GABA-mediated inhibition in the hypovolaemia-induced vasopressin release.

Knepel W, Nutto D, Hertting G Pflugers Arch. 1980; 388(2):177-83.

PMID: 7192856 DOI: 10.1007/BF00584125.

References

Arnold E, Molinoff P, RUTLEDGE C . The release of endogenous norepinephrine and dopamine from cerebral cortex by amphetamine. J Pharmacol Exp Ther. 1977; 202(3):544-57. View

Urano A, Kobayashi H . Effects of noradrenaline and dopamine injected into the supraoptic nucleus on urine flow rate in hydrated rats. Exp Neurol. 1978; 60(1):140-50. DOI: 10.1016/0014-4886(78)90173-5. View

McDonald K, Kuruvila K, Aisenbrey G, Schrier R . Effect of alpha and beta adrenergic stimulation on renal water excretion and medullary tissue cyclic AMP in intact and diabetes insipidus rats. Kidney Int. 1977; 12(2):96-103. DOI: 10.1038/ki.1977.86. View

Lum G, Aisenbrey G, Dunn M, Berl T, Schrier R, McDonald K . In vivo effect of indomethacin to potentiate the renal medullary cyclic AMP response to vasopressin. J Clin Invest. 1977; 59(1):8-13. PMC: 333326. DOI: 10.1172/JCI108624. View

Anderson R, Pluss R, Berns A, Jackson J, Arnold P, Schrier R . Mechanism of effect of hypoxia on renal water excretion. J Clin Invest. 1978; 62(4):769-77. PMC: 371828. DOI: 10.1172/JCI109188. View

Hoffman W, Phillips M, Schmid P . The role of catecholamines in central antidiuretic and pressor mechanisms. Neuropharmacology. 1977; 16(9):563-9. DOI: 10.1016/0028-3908(77)90025-9. View

Halter J, Goldberg A, Robertson G, Porte Jr D . Selective osmoreceptor dysfunction in the syndrome of chronic hypernatremia. J Clin Endocrinol Metab. 1977; 44(4):609-16. DOI: 10.1210/jcem-44-4-609. View

Barker J, Crayton J, Nicoll R . Noradrenaline and acetylcholine responses of supraoptic neurosecretory cells. J Physiol. 1971; 218(1):19-32. PMC: 1331582. DOI: 10.1113/jphysiol.1971.sp009602. View

MILTON A, Paterson A . A microinjection study of the control of antidiuretic hormone release by the supraoptic nucleus of the hypothalamus in the cat. J Physiol. 1974; 241(3):607-28. PMC: 1331053. DOI: 10.1113/jphysiol.1974.sp010674. View

10.

Schmitt H, FENARD S . Action of -adrenergic blocking drugs on the sympathetic centres and their interactions with the central sympatho-inhibitory effect of clonidine. Arzneimittelforschung. 1973; 23(1):40-5. View

11.

Kostrzewa R, Jacobowitz D . Pharmacological actions of 6-hydroxydopamine. Pharmacol Rev. 1974; 26(3):199-288. View

12.

Beck N, Reed S, MURDAUGH H, Davis B . Effects of catecholamines and their interaction with other hormones on cyclic 3',5'-adenosine monophosphate of the kidney. J Clin Invest. 1972; 51(4):939-44. PMC: 302207. DOI: 10.1172/JCI106888. View

13.

Schrier R, Lieberman R, Ufferman R . Mechanism of antidiuretic effect of beta adrenergic stimulation. J Clin Invest. 1972; 51(1):97-111. PMC: 332934. DOI: 10.1172/JCI106803. View

14.

Handler J, Bensinger R, ORLOFF J . Effect of adrenergic agents on toad bladder response to ADH, 3',5'-AMP, and theophylline. Am J Physiol. 1968; 215(5):1024-31. DOI: 10.1152/ajplegacy.1968.215.5.1024. View

15.

Henry D, Starman B, Johnson D, Williams R . A sensitive radioenzymatic assay for norepinephrine in tissues and plasma. Life Sci. 1975; 16(3):375-84. DOI: 10.1016/0024-3205(75)90258-1. View

16.

Schrier R, Berl T . Nonosmolar factors affecting renal water excretion (first of two parts). N Engl J Med. 1975; 292(2):81-8. DOI: 10.1056/NEJM197501092920207. View

17.

Kuhn E . Cholinergic and adrenergic release mechanism for vasopressin in the male rat: a study with injections of neurotransmitters and blocking agents into the third ventricle. Neuroendocrinology. 1974; 16(5-6):255-64. DOI: 10.1159/000122572. View

18.

Cadnapaphornchai P, Boykin J, Berl T, McDonald K, Schrier R . Mechanism of effect of nicotine on renal water excretion. Am J Physiol. 1974; 227(5):1216-20. DOI: 10.1152/ajplegacy.1974.227.5.1216. View

19.

Peeters G . Effects of intraventricular administration of cholinergic drugs on water diuresis in goats. Arch Int Pharmacodyn Ther. 1974; 211(1):80-98. View

20.

Berl T, Harbottle J, Schrier R . Effect of alpha- and beta-adrenergic stimulation on renal water excretion in man. Kidney Int. 1974; 6(4):247-53. DOI: 10.1038/ki.1974.106. View