Selective Mediation of Kappa-opioid Central Cardiovascular Effects by Ascending Noradrenergic Pathways

Overview

Journal Exp Brain Res

Specialty Neurology

Date 1987 Jan 1

PMID 3556499

Citations 1

Authors

D A Carter

S L Lightman

Affiliations

Soon will be listed here.

Abstract

The role of ascending noradrenergic pathways in the mediation of central opiate-induced cardiovascular effects has been investigated. The effects of selective kappa- and delta-opiate agonists microinjected into the nucleus tractus solitarius (NTS) of urethane anaesthetized rats were compared following 6-hydroxydopamine lesions of either the dorsal (DNAB) or ventral (VNAB) noradrenergic bundles. In sham lesioned animals both opiates elicited a significant pressor effect and a variable but consistent bradycardia. The delta-agonist responses were not modified in lesioned rats. In marked contrast the pressor effect of the kappa-agonist was abolished in both DNAB and VNAB lesioned rats. The bradycardic response was not significantly modified. These findings are consistent with previous observations that the cardiovascular effects of kappa- and delta-opiates in the NTS are mediated via different mechanisms, and provide evidence for selective functional actions of endogenous opioids within brain nuclei.

Citing Articles

Onasemnogene-abeparvovec administration to premature infants with spinal muscular atrophy.

Brown S, Ajjarapu A, Ramachandra D, Blasco-Perez L, Costa-Roger M, Tizzano E Ann Clin Transl Neurol. 2024; 11(11):3042-3046.

PMID: 39342433 PMC: 11572727. DOI: 10.1002/acn3.52213.

References

Yamane Y, Nakai M, Yamamoto J, Umeda Y, Ogino K . Release of vasopressin by electrical stimulation of the intermediate portion of the nucleus of the tractus solitarius in rats with cervical spinal cordotomy and vagotomy. Brain Res. 1984; 324(2):358-60. DOI: 10.1016/0006-8993(84)90049-0. View

Palkovits M, Zaborszky L . Neuroanatomy of central cardiovascular control. Nucleus tractus solitarii: afferent and efferent neuronal connections in relation to the baroreceptor reflex arc. Prog Brain Res. 1977; 47:9-34. DOI: 10.1016/S0079-6123(08)62709-0. View

Brooks D, Share L, Crofton J . Central adrenergic control of vasopressin release. Neuroendocrinology. 1986; 42(5):416-20. DOI: 10.1159/000124480. View

Carter D, Lightman S . Selective cardiovascular and neuroendocrine effects of a kappa-opioid agonist in the nucleus tractus solitarii of rats. J Physiol. 1985; 367:363-75. PMC: 1193068. DOI: 10.1113/jphysiol.1985.sp015829. View

Day T, Renaud L . Electrophysiological evidence that noradrenergic afferents selectively facilitate the activity of supraoptic vasopressin neurons. Brain Res. 1984; 303(2):233-40. DOI: 10.1016/0006-8993(84)91209-5. View

Martin R, Bailey B, Downer R . Rapid estimation of catecholamines, octopamine and 5-hydroxytryptamine in biological tissues using high-performance liquid chromatography with coulometric detection. J Chromatogr. 1983; 278(2):265-74. DOI: 10.1016/s0378-4347(00)84785-4. View

Day T, Ferguson A, Renaud L . Facilitatory influence of noradrenergic afferents on the excitability of rat paraventricular nucleus neurosecretory cells. J Physiol. 1984; 355:237-49. PMC: 1193488. DOI: 10.1113/jphysiol.1984.sp015416. View

Watson S, Khachaturian H, Akil H, Coy D, Goldstein A . Comparison of the distribution of dynorphin systems and enkephalin systems in brain. Science. 1982; 218(4577):1134-6. DOI: 10.1126/science.6128790. View

Spyer K . Neural organisation and control of the baroreceptor reflex. Rev Physiol Biochem Pharmacol. 1981; 88:24-124. View

10.

Lee H, Basbaum A . Immunoreactive pro-enkephalin and prodynorphin products are differentially distributed within the nucleus of the solitary tract of the rat. J Comp Neurol. 1984; 230(4):614-9. DOI: 10.1002/cne.902300409. View

11.

Lightman S, Todd K, Everitt B . Ascending noradrenergic projections from the brainstem: evidence for a major role in the regulation of blood pressure and vasopressin secretion. Exp Brain Res. 1984; 55(1):145-51. DOI: 10.1007/BF00240508. View

12.

Lightman S, Todd K, Everitt B . Role for lateral tegmental noradrenergic neurons in the vasopressin response to hypertonic saline. Neurosci Lett. 1983; 42(1):55-9. DOI: 10.1016/0304-3940(83)90421-4. View

13.

Kubo T, Amano H, Katsumata M, Misu Y . Involvement of central catecholamines in mediation of pressor responses of the rat to carotid occlusion. Naunyn Schmiedebergs Arch Pharmacol. 1985; 328(3):348-50. DOI: 10.1007/BF00515565. View

14.

PETTY M, de Jong W . Enkephalins induce a centrally mediated rise in blood pressure in rats. Brain Res. 1983; 260(2):322-5. DOI: 10.1016/0006-8993(83)90689-3. View

15.

Miller T, Handelman W, Arnold P, McDonald K, Molinoff P, Schrier R . Effect of central catecholamine depletion on the osmotic and nonosmotic stimulation of vasopressin (antidiuretic hormone) in the rat. J Clin Invest. 1979; 64(6):1599-607. PMC: 371313. DOI: 10.1172/JCI109621. View

16.

Banks D, Harris M . Lesions of the locus coeruleus abolish baroreceptor-induced depression of supraoptic neurones in the rat. J Physiol. 1984; 355:383-98. PMC: 1193497. DOI: 10.1113/jphysiol.1984.sp015425. View

17.

Millan M, Millan M, Czlonkowski A, Herz A . Contrasting interactions of the locus coeruleus as compared to the ventral noradrenergic bundle with CNS and pituitary pools of vasopressin, dynorphin and related opioid peptides in the rat. Brain Res. 1984; 298(2):243-52. DOI: 10.1016/0006-8993(84)91424-0. View

18.

Sawchenko P, Swanson L . The organization of noradrenergic pathways from the brainstem to the paraventricular and supraoptic nuclei in the rat. Brain Res. 1982; 257(3):275-325. DOI: 10.1016/0165-0173(82)90010-8. View