Some Biological Effects of Carbamoyloxyurea, an Oxidation Product of Hydroxyurea

Overview

Journal J Bacteriol

Publisher American Society for Microbiology

Specialty Microbiology

Date 1970 Apr 1

PMID 4908673

Citations 6

Authors

H S Rosenkranz

Affiliations

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Abstract

Carbamoyloxyurea, an oxidation product of hydroxyurea, is bactericidal for Escherichia coli. Drug-induced killing is independent of cellular metabolism; ribonucleic acid and protein syntheses are the processes most affected, and the lethal action is accompanied by degradation of cellular deoxyribonucleic acid. In all of these effects the drug differs from hydroxyurea, a primarily bacteriostatic agent that inhibits deoxyribonucleic acid synthesis, whose lethal action ultimately depends on cellular activity.

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An effect of hydroxyurea on Staphylococcus epidermidis: temporary loss of viability.

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[Studies on synchronisation in vivo: temporary inhibition of DNA synthesis in normal and malignant mammalian cell systems with hydroxyurea].

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Increased DNA polymerase and ATP-dependent deoxyribonuclease activities following DNA damages in mycobacterium smegmatis.

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