An Effect of Hydroxyurea on Staphylococcus Epidermidis: Temporary Loss of Viability

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 1973 Sep 1

PMID 4790554

Citations 1

Authors

R R FEINER

H S Rosenkranz

J E Coward

Affiliations

Soon will be listed here.

Abstract

Although hydroxyurea (HU) is recognized as a specific inhibitor of deoxyribonucleic acid (DNA) synthesis, it did not have this effect in a strain of Staphylococcus epidermidis. In this case, HU caused a loss of colony-forming ability but did not prevent cell division in liquid medium. DNA synthesis apparently was affected only secondarily. About 10% of the population recovered colony-forming ability during the latter part of the growth cycle or when growth was slowed by chloramphenicol. Recovery also occurred when HU was removed from the medium. HU prevented cellular autolysis.

Citing Articles

Effect of hydroxyurea on Staphylococcus epidermidis and Micrococcus lysodeikticus: thickening of the cell wall.

FEINER R, Coward J, Rosenkranz H Antimicrob Agents Chemother. 1973; 3(3):432-5.

PMID: 4790602 PMC: 444427. DOI: 10.1128/AAC.3.3.432.

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