Hydroxyurea Reduces Infections in Children with Sickle Cell Anemia in Uganda

Overview

Journal Blood

Publisher Elsevier

Specialty Hematology

Date 2024 Jan 3

PMID 38169476

Authors

Ruth Namazzi

Caitlin Bond

Andrea L Conroy

Dibyadyuti Datta

Abner Tagoola

Michael J Goings

Jeong Hoon Jang

Russell E Ware

Robert Opoka

Chandy C John

Affiliations

Soon will be listed here.

Abstract

After starting hydroxyurea treatment, Ugandan children with sickle cell anemia had 60% fewer severe or invasive infections, including malaria, bacteremia, respiratory tract infections, and gastroenteritis, than before starting hydroxyurea treatment (incidence rate ratio, 0.40 [95% confidence interval, 0.29-0.54]; P < .001).

Citing Articles

Incident Stroke in Pediatric Sickle cell Anemia Despite Overall Improved Transcranial Doppler Velocity in a Ugandan Hydroxyurea Trial: Antecedent and ongoing risks.

Wambaka B, Mpungu A, Mboizi V, Kalibbala D, Nambatya G, Murungi S medRxiv. 2025; .

PMID: 39974085 PMC: 11838932. DOI: 10.1101/2025.01.28.25320389.

Infections in sickle cell disease.

Scourfield L, Nardo-Marino A, Williams T, Rees D Haematologica. 2024; 110(3):546-561.

PMID: 39568431 PMC: 11873697. DOI: 10.3324/haematol.2024.285066.

Adherence to Hydroxyurea and Patients' Perceptions of Sickle Cell Disease and Hydroxyurea: A Cross-Sectional Study.

Madkhali M, Abusageah F, Hakami F, Zogel B, Hakami K, Alfaifi S Medicina (Kaunas). 2024; 60(1).

PMID: 38256385 PMC: 10819561. DOI: 10.3390/medicina60010124.

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